麻醉机制：细胞和分子水平上的靶蛋白研究进展

Title:Anesthetics Mechanisms: A Review of Putative Target Proteins at the Cellular and Molecular Level

Volume: 19 Issue: 11

关键词: 麻醉剂，靶蛋白，G蛋白偶联受体，配体门控离子通道，CAMkinase，整合素，细胞骨架，SIRT2脱乙酰酶。

摘要: Despite widespread clinical use of anesthetics, the exact mechanisms of anesthetic action are unclear. In terms of physiological action, a broad mechanism of general anesthesia including perturbations of neurotransmission has been suggested. However, the mechanism of anesthetic action at the molecular level is less clear. Specifically, how anesthetics affect neurons and glial cells and which proteins they interact with remains to be explored. Several recent studies have investigated the molecular interactions between proteins and anesthetics. In this review, we summarize the molecular mechanisms of anesthetic action in the intracellular signaling pathways of neuronal and glial cells.

Cite this article as:

Anesthetics Mechanisms: A Review of Putative Target Proteins at the Cellular and Molecular Level, Current Drug Targets 2018; 19 (11) . https://dx.doi.org/10.2174/1389450119666180502112029