摘要
尽管麻醉药在临床上得到了广泛的应用,但麻醉作用的确切机制尚不清楚。从生理作用的角度来看,包括神经传导紊乱在内的全身麻醉的广泛机制已被提出。然而,在分子水平上麻醉作用的机制尚不清楚,尤其是麻醉剂如何影响神经元和胶质细胞,以及它们与哪些蛋白质相互作用仍有待进一步研究。最近的几项研究对蛋白质与麻醉药之间的分子相互作用进行了研究。本文就麻醉作用在神经元和胶质细胞内信号通路中的分子机制作一综述。
关键词: 麻醉剂,靶蛋白,G蛋白偶联受体,配体门控离子通道,CAMkinase,整合素,细胞骨架,SIRT2脱乙酰酶。
图形摘要
Current Drug Targets
Title:Anesthetics Mechanisms: A Review of Putative Target Proteins at the Cellular and Molecular Level
Volume: 19 Issue: 11
关键词: 麻醉剂,靶蛋白,G蛋白偶联受体,配体门控离子通道,CAMkinase,整合素,细胞骨架,SIRT2脱乙酰酶。
摘要: Despite widespread clinical use of anesthetics, the exact mechanisms of anesthetic action are unclear. In terms of physiological action, a broad mechanism of general anesthesia including perturbations of neurotransmission has been suggested. However, the mechanism of anesthetic action at the molecular level is less clear. Specifically, how anesthetics affect neurons and glial cells and which proteins they interact with remains to be explored. Several recent studies have investigated the molecular interactions between proteins and anesthetics. In this review, we summarize the molecular mechanisms of anesthetic action in the intracellular signaling pathways of neuronal and glial cells.
Export Options
About this article
Cite this article as:
Anesthetics Mechanisms: A Review of Putative Target Proteins at the Cellular and Molecular Level, Current Drug Targets 2018; 19 (11) . https://dx.doi.org/10.2174/1389450119666180502112029
DOI https://dx.doi.org/10.2174/1389450119666180502112029 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
Related Books

- Author Guidelines
- Bentham Author Support Services (BASS)
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Oncolytic Herpes Simplex Virus Type 1 and Host Immune Responses
Current Cancer Drug Targets An Overview of Nanoformulated Nutraceuticals and their Therapeutic Approaches
Current Nutrition & Food Science Expression of NRP-1 and NRP-2 in Endometrial Cancer
Current Pharmaceutical Biotechnology Glucose-6-Phosphate Dehydrogenase Deficiency: Disadvantages and Possible Benefits
Cardiovascular & Hematological Disorders-Drug Targets Sunlight Vitamin D and Skin Cancer
Anti-Cancer Agents in Medicinal Chemistry Nitric Oxide in Health and Disease from the Point of View of the Otorhinolaryngologist
Current Pharmaceutical Design Airway Fibroblast Secretory Products Enhance Cell Migration
Current Proteomics Molecular and Biochemical Pathways Encompassing Diabetes Mellitus and Dementia
CNS & Neurological Disorders - Drug Targets Anti-Epidermal Growth Factor Receptor Strategies to Enhance Radiation Action
Current Medicinal Chemistry - Anti-Cancer Agents Salivary Genomics, Transcriptomics and Proteomics: The Emerging Concept of the Oral Ecosystem and their Use in the Early Diagnosis of Cancer and other Diseases
Current Genomics Topical Chemoprevention of Skin Cancers with Phytochemicals
Current Cancer Therapy Reviews Cancer Proteomics: New Horizons and Insights into Therapeutic Applications
Current Proteomics Using Nutrigenomics to Evaluate Apoptosis as a Preemptive Target in Cancer Prevention
Current Cancer Drug Targets Biological Applications of ZnO Nanoparticles
Current Molecular Imaging (Discontinued) Targeted Drug Delivery in Brain Tumors-nanochemistry Applications and Advances
Current Topics in Medicinal Chemistry Targeted Drug Delivery to the Virus-Infected Airway; Complications and Remedies
Current Drug Delivery Expression and Function of Kruppel Like-Factors (KLF) in Carcinogenesis
Current Genomics Cytotoxic and Chemopreventive Effects of Gemin D Against Different Mutagens Using In Vitro and In Vivo Assays
Anti-Cancer Agents in Medicinal Chemistry Curcumin: Powerful Immunomodulator from Turmeric
Current Immunology Reviews (Discontinued) Tubulin Colchicine Binding Site Inhibitors as Vascular Disrupting Agents in Clinical Developments
Current Medicinal Chemistry