Abstract
Voltage-dependent anion channels (VDAC) are major constituents of the outer mitochondrial membrane. Over the past few years, several hypotheses and mechanisms have been forwarded for and against a role for VDAC in outer mitochondrial membrane permeability and the subsequent release of apoptosis promoting factors. The current review outlines current knowledge related to the role of VDAC in the regulation of cell death and speculates on possible therapeutic applications through VDAC modulation.
Keywords: mitochondria, apoptosis, vdac, heart, cytochrome c, cell death
Current Medicinal Chemistry
Title: The Mitochondrial Voltage-dependent Anion Channel (VDAC) as a Therapeutic Target for Initiating Cell Death
Volume: 10 Issue: 16
Author(s): David J. Granville and Roberta A. Gottlieb
Affiliation:
Keywords: mitochondria, apoptosis, vdac, heart, cytochrome c, cell death
Abstract: Voltage-dependent anion channels (VDAC) are major constituents of the outer mitochondrial membrane. Over the past few years, several hypotheses and mechanisms have been forwarded for and against a role for VDAC in outer mitochondrial membrane permeability and the subsequent release of apoptosis promoting factors. The current review outlines current knowledge related to the role of VDAC in the regulation of cell death and speculates on possible therapeutic applications through VDAC modulation.
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Cite this article as:
Granville J. David and Gottlieb A. Roberta, The Mitochondrial Voltage-dependent Anion Channel (VDAC) as a Therapeutic Target for Initiating Cell Death, Current Medicinal Chemistry 2003; 10 (16) . https://dx.doi.org/10.2174/0929867033457214
DOI https://dx.doi.org/10.2174/0929867033457214 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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