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Current Medical Imaging

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ISSN (Print): 1573-4056
ISSN (Online): 1875-6603

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Research Article

Assessment of Auditory Pathways Using Diffusion Tensor Imaging in Patients with Neurofibromatosis Type 1

Author(s): Sedat Meydan*, Sinem Aydin, Hafize Otcu, Serkan Kitis and Alpay Alkan

Volume 15, Issue 9, 2019

Page: [890 - 894] Pages: 5

DOI: 10.2174/1573405614666180425124743

open_access

Abstract

Aim: The aim of our study was to determine whether the diffusion properties of the auditory pathways alter between patients with Neurofibromatosis type 1 (NF1) and the healthy subjects. DTI can well demonstrate FA and ADC changes in auditory tracts and it may be a guide to identify the candidates for hearing loss among NF1 children.

Methods: The study population consisted of 43 patients with NF1 and 21 healthy controls. Diffusion tensor imaging (DTI) was used to measure apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values from lemniscus lateralis, colliculus inferior, corpus geniculatum mediale and Heschl's gyrus. The results were compared with those of the control group.

Results: The ADC values of lateral lemniscus, colliculus inferior and corpus geniculatum mediale were significantly higher in NF1 compared to those of the control group. On the other hand, decreased FA values were observed in lateral lemniscus and colliculus inferior in patients with NF1.

Conclusion: The increase in ADC and reduction in FA in the auditory pathways of patients with NF1 may suggest microstructural alterations, such as a decrease in the number of axons, edema or inflammation in the auditory tracts.

Keywords: NF1, diffusion tensor imaging, Heschl's gyrus, colliculus inferior, mediale, corpus geniculatum.

Graphical Abstract

[1]
North K. Neurofibromatosis type 1. Am J Med Genet 2000; 97(2): 119-27.
[http://dx.doi.org/10.1002/1096-8628(200022)97:2<119:AID-AJMG3>3.0.CO;2-3] [PMID: 11180219]
[2]
Erdoğan H, Karaoğlan A. Nörofibromatozis Tip 2. Türk Nöroşir Derg 2016; 26: 92.
[3]
Batista PB, Lemos SM, Rodrigues LO, de Rezende NA. Auditory temporal processing deficits and language disorders in patients with neurofibromatosis type 1. J Commun Disord 2014; 48: 18-26.
[http://dx.doi.org/10.1016/j.jcomdis.2013.12.002] [PMID: 24447521]
[4]
Kurtcan S, Alkan A, Kilicarslan R, et al. Auditory pathway features determined by DTI in subjects with unilateral acoustic neuroma. Clin Neuroradiol 2016; 26(4): 439-44.
[http://dx.doi.org/10.1007/s00062-015-0385-z] [PMID: 25813527]
[5]
Kurtcan S, Hatiboglu MA, Alkan A, et al. Evaluation of auditory pathways using DTI in Patients treated with gamma knife radiosurgery for acoustic neuroma: A preliminary report. Clin Neuroradiol 2018; 28(3): 377-83.
[http://dx.doi.org/10.1007/s00062-017-0572-1] [PMID: 28258282]
[6]
Wu CM, Ng SH, Wang JJ, Liu TC. Diffusion tensor imaging of the subcortical auditory tract in subjects with congenital cochlear nerve deficiency. AJNR Am J Neuroradiol 2009; 30(9): 1773-7.
[http://dx.doi.org/10.3174/ajnr.A1681] [PMID: 19574496]
[7]
Mukherjee P, Miller JH, Shimony JS, et al. Diffusion-tensor MR imaging of gray and white matter development during normal human brain maturation. AJNR Am J Neuroradiol 2002; 23(9): 1445-56.
[PMID: 12372731]
[8]
Nakayama N, Okumura A, Shinoda J, et al. Evidence for white matter disruption in traumatic brain injury without macroscopic lesions. J Neurol Neurosurg Psychiatry 2006; 77(7): 850-5.
[http://dx.doi.org/10.1136/jnnp.2005.077875] [PMID: 16574734]
[9]
Standring S. Gray’s Anatomy, The anatomical basis of clinical practice, section 4, head and neck. 40th ed. Amsterdam: Elsevier Ltd. 2008.
[10]
Ertan G, Zan E, Yousem DM, et al. Diffusion tensor imaging of neurofibromatosis bright objects in children with neurofibromatosis type 1. Neuroradiol J 2014; 27(5): 616-26.
[http://dx.doi.org/10.15274/NRJ-2014-10055] [PMID: 25260209]
[11]
Alkan A, Sigirci A, Kutlu R, et al. Neurofibromatosis type 1: diffusion weighted imaging findings of brain. Eur J Radiol 2005; 56(2): 229-34.
[http://dx.doi.org/10.1016/j.ejrad.2005.05.008] [PMID: 15963674]
[12]
Sheikh SF, Kubal WS, Anderson AW, Mutalik P. Longitudinal evaluation of apparent diffusion coefficient in children with neurofibromatosis type 1. J Comput Assist Tomogr 2003; 27(5): 681-6.
[http://dx.doi.org/10.1097/00004728-200309000-00004] [PMID: 14501358]
[13]
Eastwood JD, Fiorella DJ, MacFall JF, Delong DM, Provenzale JM, Greenwood RS. Increased brain apparent diffusion coefficient in children with neurofibromatosis type 1. Radiology 2001; 219(2): 354-8.
[http://dx.doi.org/10.1148/radiology.219.2.r01ap25354] [PMID: 11323456]
[14]
Aydin S, Kurtcan S, Alkan A, et al. Relationship between the corpus callosum and neurocognitive disabilities in children with NF-1: diffusion tensor imaging features. Clin Imaging 2016; 40(6): 1092-5.
[http://dx.doi.org/10.1016/j.clinimag.2016.06.013] [PMID: 27423006]
[15]
Lin YC, Wang CC, Wai YY, et al. Significant temporal evolution of diffusion anisotropy for evaluating early response to radiosurgery in patients with vestibular schwannoma: findings from functional diffusion maps. AJNR Am J Neuroradiol 2010; 31(2): 269-74.
[http://dx.doi.org/10.3174/ajnr.A1799] [PMID: 19779002]
[16]
Wang L, Goldstein FC, Veledar E, et al. Alterations in cortical thickness and white matter integrity in mild cognitive impairment measured by whole-brain cortical thickness mapping and diffusion tensor imaging. AJNR Am J Neuroradiol 2009; 30(5): 893-9.
[http://dx.doi.org/10.3174/ajnr.A1484] [PMID: 19279272]
[17]
Mukherjee P, Chung SW, Berman JI, Hess CP, Henry RG. Diffusion tensor MR imaging and fiber tractography: technical considerations. AJNR Am J Neuroradiol 2008; 29(5): 843-52.
[http://dx.doi.org/10.3174/ajnr.A1052] [PMID: 18339719]

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