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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Review Article

Key Updates on the Chemistry and Biological Roles of Thiazine Scaffold: A Review

Author(s): Shalki Choudhary, Om Silakari* and Pankaj Kumar Singh

Volume 18, Issue 17, 2018

Page: [1452 - 1478] Pages: 27

DOI: 10.2174/1389557518666180416150552

Price: $65

Abstract

Nitrogen and sulphur based heterocyclic molecules have gained significant attention owing to their broad spectrum pharmacological profiles. Thiazine is one of such promising scaffolds which has been widely utilized in the synthesis of compounds that possess interesting biological profile including anti-proliferative, anti-bacterial, antipsychotic, analgesic, anti-inflammatory, antifungal and antiviral activities. The current review focuses on the chemistry of thiazine and its derivatives along with potential pharmacological activities reported for these in scientific literature. Multifaceted pharmacological profile of thiazine derivatives provides new aspects for the design of superior medicinally active agents.

Keywords: Thiazine, antimicrobial, antifungal, antimalarial, anticancer, thiazine scaffold.

Graphical Abstract


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