摘要
患有帕金森病(PD)的患者期待新的治疗策略可能逐渐减缓神经退行性衰退的速度,与行动限制和相关的发病率相关。其持续的神经退行性过程,由基因突变或环境毒素加剧,涉及多巴胺神经传递水平,突触摄取密度,氧化葡萄糖摄入,纹状体乳酸积累不足和慢性炎症的逐渐减少。在过去十年中,新型生物制品因其独特的营养,安全和治疗自然效果的独特潜力而备受关注。一些营养保健品在控制PD中神经传递和炎症中的信号转导途径中起关键作用,并且一些天然化合物可以有益地与这些生物机制中的每一种相互作用以减缓疾病进展。 Atremorine是一种新型植物衍生的营养保健品,可能在黑质多巴胺能神经元(pars compacta)中具有神经保护作用,是这种新型生物制品的原型,对PD有潜在影响。本次评价的主要重点是通过植物衍生的神经保护方法改善PD患者的生活质量,对当前的知识和生物医学调查策略,对于医疗服务提供者,护理人员和患者本身至关重要。
关键词: 帕金森病,多巴胺激动剂,PD动物模型,神经病理学,生物疗法,atremorine
Current Medicinal Chemistry
Title:Dopaminergic Neuroprotection with Atremorine in Parkinson´s Disease
Volume: 25 Issue: 39
关键词: 帕金森病,多巴胺激动剂,PD动物模型,神经病理学,生物疗法,atremorine
摘要: Patients with Parkinson’s disease (PD) are looking forward to new therapeutic strategies that may gradually decelerate the rate of neurodegenerative decline, associated with mobility restrictions and related morbidity. Its continuous neurodegenerative process, exacerbated by genetic mutations or environmental toxins, involves a progressive reduction in the dopamine neurotransmission levels, synaptic uptake density, oxidative glucose intake, deficient striatal lactate accumulation and chronic inflammation. Over the last decade, novel bioproducts have received considerable interest due to their unique potential of unifying nutritional, safety and therapeutic natural effects. Some nutraceuticals play a crucial role in the control of the signaling transduction pathways in neurotransmission and inflammation affected in PD, and some natural compounds can beneficially interact with each one of these biological mechanisms to slow down disease progression. Atremorine, a novel plant-derived nutraceutical, probably with a neuroprotective effect in the dopaminergic neurons of the substantia nigra (pars compacta), is a prototype of this new category of bioproducts with potential effects in PD. The major focus of this review will be on the current knowledge and biomedical investigation strategies through a plant-derived neuroprotective approach to improve life quality in PD patients, being of paramount importance for health providers, caregivers and the patients themselves.
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Cite this article as:
Dopaminergic Neuroprotection with Atremorine in Parkinson´s Disease, Current Medicinal Chemistry 2018; 25 (39) . https://dx.doi.org/10.2174/0929867325666180410100559
DOI https://dx.doi.org/10.2174/0929867325666180410100559 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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