Chemistry of Bis-Spiroacetal Systems: Natural Products, Synthesis and Stereochemistry

Title: Chemistry of Bis-Spiroacetal Systems: Natural Products, Synthesis and Stereochemistry

Volume: 7 Issue: 14

Author(s): Margaret A. Brimble and Daniel P. Furkert

Affiliation:

Abstract: In recent years a number of compounds containing bis-spiroacetal systems have been isolated from nature. Predominantly of dinoflagellate origin, they have stimulated much synthetic interest due to their potent biological activity and synthetically challenging structural features. Although the chemistry of bicyclic spiroacetals is well understood, that of the tricyclic bis-spiroacetals has been less fully explored. This review describes the strategies employed to construct bis-spiroacetals with particular reference to stereochemical issues associated with the quaternary spirocentres.

Cite this article as:

Brimble A. Margaret and Furkert P. Daniel, Chemistry of Bis-Spiroacetal Systems: Natural Products, Synthesis and Stereochemistry, Current Organic Chemistry 2003; 7 (14) . https://dx.doi.org/10.2174/1385272033486404