Abstract
In recent years a number of compounds containing bis-spiroacetal systems have been isolated from nature. Predominantly of dinoflagellate origin, they have stimulated much synthetic interest due to their potent biological activity and synthetically challenging structural features. Although the chemistry of bicyclic spiroacetals is well understood, that of the tricyclic bis-spiroacetals has been less fully explored. This review describes the strategies employed to construct bis-spiroacetals with particular reference to stereochemical issues associated with the quaternary spirocentres.
Current Organic Chemistry
Title: Chemistry of Bis-Spiroacetal Systems: Natural Products, Synthesis and Stereochemistry
Volume: 7 Issue: 14
Author(s): Margaret A. Brimble and Daniel P. Furkert
Affiliation:
Abstract: In recent years a number of compounds containing bis-spiroacetal systems have been isolated from nature. Predominantly of dinoflagellate origin, they have stimulated much synthetic interest due to their potent biological activity and synthetically challenging structural features. Although the chemistry of bicyclic spiroacetals is well understood, that of the tricyclic bis-spiroacetals has been less fully explored. This review describes the strategies employed to construct bis-spiroacetals with particular reference to stereochemical issues associated with the quaternary spirocentres.
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Cite this article as:
Brimble A. Margaret and Furkert P. Daniel, Chemistry of Bis-Spiroacetal Systems: Natural Products, Synthesis and Stereochemistry, Current Organic Chemistry 2003; 7 (14) . https://dx.doi.org/10.2174/1385272033486404
DOI https://dx.doi.org/10.2174/1385272033486404 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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