Abstract
The leukocyte integrins are essential membrane receptors that mediate leukocyte adhesion to various cells during immune and inflammatory responses including tumor cell killing, leukocyte migration from the bloodstream into inflamed tissues, and phagocytosis of bacteria. The importance of these receptors is underscored in humans with leukocyte adhesion deficiency (LAD), that is caused by the absence or greatly reduced expression of the leukocyte integrins on leukocytes, and which leads to recurrent life-threatening infections and impaired wound healing. These receptors can also exacerbate the diseased state when excessive accumulation of leukocytes occurs at the site of inflammation because of overexpression or increased activation of the leukocyte integrins on these cells. These receptors are involved in a variety of pathological conditions in the vascular system including ischemic reperfusion injury, stroke, and atherosclerosis. The leukocyte integrins augment tissue damage that occurs in autoimmune diseases including rheumatoid arthritis, multiple sclerosis, Crohns disease, and ulcerative colitis. This review will focus on the molecular mechanisms that regulate activation of the leukocyte integrins including transcriptional control of leukocyte gene expression and the role these receptors play in normal and pathological inflammatory processes. Their potential use as markers for disease diagnosis and the prospects for anti-adhesion therapy to ameliorate disease as indicted in a number of animal models will be discussed.
Keywords: leukocyte integrins, inflammation, autoimmune disease, vascular disease
Current Genomics
Title: Expression and Function of the Leukocyte Integrins in Medicine
Volume: 4 Issue: 6
Author(s): John D. Noti
Affiliation:
Keywords: leukocyte integrins, inflammation, autoimmune disease, vascular disease
Abstract: The leukocyte integrins are essential membrane receptors that mediate leukocyte adhesion to various cells during immune and inflammatory responses including tumor cell killing, leukocyte migration from the bloodstream into inflamed tissues, and phagocytosis of bacteria. The importance of these receptors is underscored in humans with leukocyte adhesion deficiency (LAD), that is caused by the absence or greatly reduced expression of the leukocyte integrins on leukocytes, and which leads to recurrent life-threatening infections and impaired wound healing. These receptors can also exacerbate the diseased state when excessive accumulation of leukocytes occurs at the site of inflammation because of overexpression or increased activation of the leukocyte integrins on these cells. These receptors are involved in a variety of pathological conditions in the vascular system including ischemic reperfusion injury, stroke, and atherosclerosis. The leukocyte integrins augment tissue damage that occurs in autoimmune diseases including rheumatoid arthritis, multiple sclerosis, Crohns disease, and ulcerative colitis. This review will focus on the molecular mechanisms that regulate activation of the leukocyte integrins including transcriptional control of leukocyte gene expression and the role these receptors play in normal and pathological inflammatory processes. Their potential use as markers for disease diagnosis and the prospects for anti-adhesion therapy to ameliorate disease as indicted in a number of animal models will be discussed.
Export Options
About this article
Cite this article as:
Noti D. John, Expression and Function of the Leukocyte Integrins in Medicine, Current Genomics 2003; 4 (6) . https://dx.doi.org/10.2174/1389202033490240
DOI https://dx.doi.org/10.2174/1389202033490240 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
Call for Papers in Thematic Issues
Current Genomics in Cardiovascular Research
Cardiovascular diseases are the main cause of death in the world, in recent years we have had important advances in the interaction between cardiovascular disease and genomics. In this Research Topic, we intend for researchers to present their results with a focus on basic, translational and clinical investigations associated with ...read more
Deep learning in Single Cell Analysis
The field of biology is undergoing a revolution in our ability to study individual cells at the molecular level, and to integrate data from multiple sources and modalities. This has been made possible by advances in technologies for single-cell sequencing, multi-omics profiling, spatial transcriptomics, and high-throughput imaging, as well as ...read more
New insights on Pediatric Tumors and Associated Cancer Predisposition Syndromes
Because of the broad spectrum of children cancer susceptibility, the diagnosis of cancer risk syndromes in children is rarely used in direct cancer treatment. The field of pediatric cancer genetics and genomics will only continue to expand as a result of increasing use of genetic testing tools. It's possible that ...read more
![](/images/wayfinder.jpg)
- Author Guidelines
- Bentham Author Support Services (BASS)
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Halogenated Derivatives of Aromatic Amino Acids Exhibit Balanced Antiglutamatergic Actions: Potential Applications for the Treatment of Neurological and Neuropsychiatric Disorders
Recent Patents on CNS Drug Discovery (Discontinued) Fibrinogen Signal Transduction as a Mediator and Therapeutic Target in Inflammation:Lessons from Multiple Sclerosis
Current Medicinal Chemistry Cardio-Hepatic Metabolic Derangements and Valproic Acid
Current Clinical Pharmacology Small Molecule Inhibitors of Phosphoinositide 3-Kinase (PI3K) δ and γ
Current Topics in Medicinal Chemistry Design, Synthesis and Evaluation of Chalcone Derivatives as Anti- Inflammatory, Antioxidant and Antiulcer Agents
Letters in Drug Design & Discovery Mitochondrial Biogenesis: Regulation By Endogenous Gases During Inflammation and Organ Stress
Current Pharmaceutical Design Ca2+ Signaling, Mitochondria and Cell Death
Current Molecular Medicine A Novel Danshensu-Tetramethylpyrazine Conjugate DT-018 Provides Cardioprotection by Preserving Mitochondrial Function Through the MEF2D/PGC-1α Pathway
Current Pharmaceutical Design Radionuclide Liver Cancer Therapies: From Concept to Current Clinical Status
Anti-Cancer Agents in Medicinal Chemistry Postoperative Atrial Fibrillation - What Do We Really Know?
Current Vascular Pharmacology Hypoxia-Inducible Factor-1α Contributes to Brain Edema after Stroke by Regulating Aquaporins and Glycerol Distribution in Brain
Current Neurovascular Research Alzheimer's Disease Prevention and Use of Traditional Plant Medicines
Letters in Drug Design & Discovery Therapeutic Potential of Carbon Monoxide (CO) for Intestinal Inflammation
Current Medicinal Chemistry Sirtuin Modulators: Mechanisms and Potential Clinical Implications
Current Medicinal Chemistry Antiplatelet and Antithrombin Strategies in Acute Coronary Syndrome: State-Of-The-Art Review
Current Cardiology Reviews Hetero-Oligomerization of Chemokine Receptors: Diversity and Relevance for Function
Current Medicinal Chemistry The VHL Tumor Suppressor: Master Regulator of HIF
Current Pharmaceutical Design Pathophysiological Roles of Nitric Oxide: In the Heart and the Coronary Vasculature
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents Proinflammatory Cytokines and Chemokines in Neonatal Brain Damage
Current Pediatric Reviews HIF Prolyl 4-Hydroxylases and their Potential as Drug Targets
Current Pharmaceutical Design