Ultrasound Assisted Cu-catalyzed Synthesis of 1,2-Disubstituted Benzimidazoles as Potential Antibacterial Agents

Title:Ultrasound Assisted Cu-catalyzed Synthesis of 1,2-Disubstituted Benzimidazoles as Potential Antibacterial Agents

Volume: 18 Issue: 14

Author(s): V. Mallikarjuna Rao, A. Srinivasa Rao*, S. Shobha Rani, S. Yasaswi and Manojit Pal*

Affiliation:

• Shri Vishnu College of Pharmacy, Bhimavaram-534202, West Godawari District, Andhra Pradesh,India

• Dr. Reddy`s Institute of Life Sciences, University of Hyderabad Campus, Gachibowli, Hyderabad 500 046,India

Keywords: Benzimidazole, ultrasound, catalyst, antibacterial, Cu-catalyzed, Gram-positive, Gram-negative.

Abstract: Background: The ultrasound assisted synthesis and anti-bacterial evaluation of a series of compounds based on 1,2-disubstituted benzimidazole framework is reported here. The approach leading to the synthesis of these compounds involved the Cu-catalyzed coupling-cyclization of N-substituted 2-iodoanilines with benzamide derivatives in the presence of 2-aminoethanol as a ligand.

Conclusion: A number of compounds were prepared using this methodology in acceptable yield. Two of these compounds showed promising antibacterial activities when tested against both Gram-positive and Gram-negative bacterial strains.

Cite this article as:

Rao Mallikarjuna V. , Rao Srinivasa A. *, Rani Shobha S. , Yasaswi S. and Pal Manojit *, Ultrasound Assisted Cu-catalyzed Synthesis of 1,2-Disubstituted Benzimidazoles as Potential Antibacterial Agents, Mini-Reviews in Medicinal Chemistry 2018; 18 (14) . https://dx.doi.org/10.2174/1389557518666180330102805