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Review Article

ADAM金属蛋白酶作为潜在的药物靶标

卷 26, 期 15, 2019

页: [2661 - 2689] 页: 29

弟呕挨: 10.2174/0929867325666180326164104

价格: $65

摘要

ADAM与ADAMTS和蛇毒金属蛋白酶（SVMP）一起是Adamalysin家族的成员。 结构组织，功能和定位的差异是已知的，它们的催化或非催化结构域在底物识别和蛋白酶活性中显示出关键作用。 一些ADAM作为膜结合酶显示出脱落酶活性。 梭形蛋白是调节功能性蛋白质的关键，例如肿瘤坏死因子，生长因子，细胞因子及其受体，粘附蛋白，信号分子和参与免疫的应激分子。 这些活动参与几种生理和病理过程的调节，包括炎症，肿瘤生长，转移进展和传染病。 在这些基础上，目前正在研究一些ADAM作为药物靶标，以在许多医学领域开发新的替代疗法。 本评论将重点关注这些方面。

关键词: 金属内肽酶，胞外域脱落，粘附分子，异羟肟酸抑制剂，锌结合基团，小分子。

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