Cytotoxic Pyran-based Cembranoids from Sarcophyton glaucum

Title:Cytotoxic Pyran-based Cembranoids from Sarcophyton glaucum

Volume: 15 Issue: 11

Author(s): Walied M. Alarif*, Zahra A. Al-Saihati, Mohamed H. Ph, Ahmed Abdel-Lateff, Mahmoud A. Elfaky, Nahed O. Bawakid, Najla A. Alburae and Hajer S. Alorfi

Affiliation:

• Department of Marine Chemistry, Faculty of Marine Sciences, King Abdulaziz University, P.O. Box 80207, Jeddah 21589,Saudi Arabia

Keywords: Soft coral, red sea, isomers, oxirane, diterpenoids, cemberane.

Abstract: Four new pyran-based cembranoidal diterpenes (1-4) were isolated from the Red Sea softbodied coral Sarcophyton glaucum. Sarcoglauphine A (1) and B (2) are conformers with respect to the dihedral angle between H-7 and the pair of H-6a, 6b, while sarcotrocheliol-B acetate (3) and sarcotrochelione (4) are bicyclic cembranoids. The chemical structures of the isolated compounds were elucidated using spectroscopic methods. The cytotoxicity of the isolated compounds were evaluated against HepG2, MCF-7, and HCT116 cell lines by employing Sulforhodamine B (SRB) method. Compounds 1 and 2 showed significant activities toward HCT116.

Cite this article as:

Alarif M. Walied *, Al-Saihati A. Zahra , Ph H. Mohamed, Abdel-Lateff Ahmed , Elfaky A. Mahmoud , Bawakid O. Nahed , Alburae A. Najla and Alorfi S. Hajer , Cytotoxic Pyran-based Cembranoids from Sarcophyton glaucum, Letters in Organic Chemistry 2018; 15 (11) . https://dx.doi.org/10.2174/1570178615666180326154819