摘要
脑缺血是导致死亡的主要原因之一,大多数病例与缺血性中风有关。它可以发生在两种形式的局灶性或全身性缺血。神经退行性疾病,如阿尔茨海默氏症和帕金森病也在全球范围内呈上升趋势。这些疾病有着共同的相似之处,即它们都会影响中枢神经系统,对病人产生衰弱的作用。本文综述了黄酮类化合物在蔬菜、水果和传统草药中的应用前景。姜黄素、番茄红素、人参皂甙、维生素E、黄芩苷等黄酮类化合物对缺血性损伤具有良好的神经保护作用。黄酮类化合物除了具有抗肿瘤、抗氧化和免疫调节作用外,还通过增加神经元活力,增加组织灌注和脑血流,减少缺血相关细胞凋亡,发挥神经保护作用。此外,类黄酮还发挥抗淀粉样作用,减少多巴胺能神经元在大脑中的损失。这些结果表明,黄酮类化合物可能是一种潜在的治疗脑疾病的药物。
关键词: 缺血,阿尔茨海默病,帕金森病,多酚,草药,天然产物。
图形摘要
Current Drug Targets
Title:Flavonoids and its Neuroprotective Effects on Brain Ischemia and Neurodegenerative Diseases
Volume: 19 Issue: 14
关键词: 缺血,阿尔茨海默病,帕金森病,多酚,草药,天然产物。
摘要: Brain ischemia is among the leading cause of death with majority of the cases are associated with ischemic strokes. It can occur in two forms of either focal or global ischemia. Neurodegenerative disorder such as Alzheimer and Parkinson diseases is also on the rise worldwide. These disorders have common similarities; i.e. they all affecting the central nervous system with debilitating effect to the patient. In this review, we look into the promising role of flavonoids, a natural bioactive compound found abundant in vegetables, fruits and traditional herbs. Treatment with flavonoids such as curcumin, lycopene, ginsenoside, vitexin and baicalin have shown promising neuroprotective effects against ischemic-induced injury. Besides anticancer, antioxidant and immunomodulation properties, flavonoid also exerts neuroprotective effects by increases neuronal viability, increases tissue perfusion and cerebral blood flow and reduce ischemic-related apoptosis. In addition, flavonoid also exerts anti-amyloidogenic effect and reduces loss of dopaminergic neurons in the brain. These results suggesting flavonoids might be able to serve as a potential therapeutic agent in brain disorders.
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Cite this article as:
Flavonoids and its Neuroprotective Effects on Brain Ischemia and Neurodegenerative Diseases, Current Drug Targets 2018; 19 (14) . https://dx.doi.org/10.2174/1389450119666180326125252
DOI https://dx.doi.org/10.2174/1389450119666180326125252 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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