摘要
上个世纪以来，许多研究表明低密度脂蛋白（LDL）是动脉粥样硬化相关心血管疾病（CVD）的关键危险因素。因此，对于这些CVD患者，临床上常用低密度脂蛋白降低剂来降低发生CVD的风险。LDL经修饰后，会产生明显的炎症和致动脉粥样硬化潜能，导致内皮完整性受损，免疫细胞大量涌入，随后泡沫细胞增多。低密度脂蛋白也能直接影响外周单核细胞的组成，使其在内皮下空间的迁移和积累处于更有利的位置。很明显，其他脂蛋白颗粒，如富含甘油三酯的脂蛋白或残余物（TRL）和脂蛋白（A）[LP（A）]也可能影响动脉粥样硬化途径。越来越多的证据表明，LP（A）能促进外周单核细胞活化，最终导致通过内皮细胞的迁移增加。同样，残余胆固醇在内皮功能障碍和单核细胞行为中也起着关键作用。在这篇综述中，我们将讨论在单核细胞和内皮细胞水平上了解不同脂蛋白在炎症中的作用的最新进展。
关键词: 脂蛋白、载脂蛋白B、脂蛋白（A）、氧化磷脂、残余物、动脉粥样硬化、单核细胞、内皮细胞。
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