摘要
氧化修饰的低密度脂蛋白（oxldl）已知参与各种疾病，包括心血管疾病。已用单克隆抗体证实在人体循环系统和动脉粥样硬化病变中存在氧化低密度脂蛋白。研究表明循环氧化低密度脂蛋白在急性心肌梗死和糖尿病等各种全身性疾病中具有重要意义。采用几种酶联免疫吸附试验（ELISA）方法测定氧化低密度脂蛋白。有证据表明，在某些病理条件下，氧化低密度脂蛋白水平发生了变化。由于氧低密度脂蛋白的浓度往往与低密度脂蛋白胆固醇相关，因此氧低密度脂蛋白与低密度脂蛋白的比例也被关注，而不仅仅是氧低密度脂蛋白的浓度。除循环血浆外，牙龈沟液（GCF）中还存在低密度脂蛋白和低密度脂蛋白，其中GCF中的低密度脂蛋白与低密度脂蛋白的比例远高于血浆。GCF中的低密度脂蛋白和氧低密度脂蛋白水平显示糖尿病患者和牙周病患者的低密度脂蛋白和氧低密度脂蛋白水平增加，这表明GCF可能有助于检查系统状况。当牙周炎影响牙齿时，GCF-Oxldl增加。血浆和GCF中的氧化低密度脂蛋白水平可能反映了循环系统中的氧化应激和转移效率。
关键词: 脂蛋白类，氧化低密度脂蛋白，氧化低密度脂蛋白/低密度脂蛋白比值，氧化磷脂酰胆碱，AMI，牙周炎，GCF，穿细胞症。
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