Radiosensitizing Effect of Cerium Oxide Nanoparticles on Human Leukemia Cells

Title:Radiosensitizing Effect of Cerium Oxide Nanoparticles on Human Leukemia Cells

Volume: 6 Issue: 2

Author(s): Azadeh Montazeri, Zohreh Zal, Arash Ghasemi, Hooman Yazdannejat, Hossein Asgarian-Omran and Seyed Jalal Hosseinimehr*

Affiliation:

• Department of Radiopharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari,Iran

Keywords: Cerium oxide nanoparticle, ionizing radiation, leukemia, nanoceria, radiosensitizing, radioresistance.

Abstract: Background: Radiotherapy is an important protocol in the treatment of cancers, but radioresistance of cancerous cells is a challenge in cancer treatment.

Objective: The aim of this study was to evaluate the radiosensitizing effect of Cerium oxide Nanoparticles (CNPs) on human promyelocytic leukemia cells (HL-60).

Method: HL-60 cells were treated with CNPs at different concentrations (10-100 μg/ml) and exposed to Ionizing Radiation (IR). The genotoxicity effects of CNPs or/and IR were assessed by micronuclei assay in HL-60 cells.

Results: It was found that CNPs increased the frequencies of micronuclei in HL-60 cells. CNPs pretreatment to irradiation significantly increased the IR-induced micronuclei incidences in HL-60 cells. The present study demonstrates CNPs to be an effective sensitizer on DNA damage induced by IR in HL-60 cells.

Conclusion: These findings suggest the potential application of CNPs as a highly effective radiosensitizer for the treatment of leukemia.

Cite this article as:

Montazeri Azadeh, Zal Zohreh, Ghasemi Arash, Yazdannejat Hooman, Asgarian-Omran Hossein and Hosseinimehr Jalal Seyed *, Radiosensitizing Effect of Cerium Oxide Nanoparticles on Human Leukemia Cells, Pharmaceutical Nanotechnology 2018; 6 (2) . https://dx.doi.org/10.2174/2211738506666180306161253