摘要
背景:肾素-血管紧张素系统(Ras)是心血管和肾脏动态平衡的重要调节因子,在中枢神经系统的生理功能调控中起着重要的作用。茎(CNS)RAS的作用被经典描述为血管紧张素(Ang)II通过血管紧张素1(AT1)受体介导。然而,血管紧张素Conv形成的RAS的另一个分支erting酶2(ACE 2)、Ang-(1-7)和Mas受体由于其重要的生理作用而成为研究的热点,通常能平衡AngⅡ的经典作用。OB目的:我们旨在概述RAS,特别是Ang-(1-7)对大脑的影响。我们还探讨了神经精神障碍的治疗潜力。RAS。 方法:在PubMed中心进行广泛的文献检索。 结果:在大脑中,Ang-(1-7)通过控制心血管功能的区域参与血压调节。与AngⅡ相比,Ang-(1-7)能改善压力反射。在下丘脑去甲肾上腺素能神经传递中起抑制作用。Ang-(1-7)不仅与血压调节有关,而且具有神经保护作用。例如,通过减少脑梗死的大小、炎症、氧化应激和神经元凋亡等。 结论:临床前证据支持ACE 2/Ang-(1-7)/mas受体轴在多种神经精神疾病中的作用,包括应激相关和心境障碍,脑血管ISC。贫血和出血性疾病和神经退行性疾病。然而,有关ACE 2/Ang-(1-7)/MAS受体轴在人中枢神经系统中的研究却很少。
关键词: 肾素-血管紧张素系统,脑,血管紧张素转换酶,血管紧张素-(1-7),马斯受体,神经精神病学。
Current Medicinal Chemistry
Title:RAS in the Central Nervous System: Potential Role in Neuropsychiatric Disorders
Volume: 25 Issue: 28
关键词: 肾素-血管紧张素系统,脑,血管紧张素转换酶,血管紧张素-(1-7),马斯受体,神经精神病学。
摘要: Background: The Renin-Angiotensin System (RAS) is a key regulator of cardiovascular and renal homeostasis, but also plays important roles in mediating physiological functions in the central nervous system (CNS). The effects of the RAS were classically described as mediated by angiotensin (Ang) II via angiotensin type 1 (AT1) receptors. However, another arm of the RAS formed by the angiotensin converting enzyme 2 (ACE2), Ang-(1-7) and the Mas receptor has been a matter of investigation due to its important physiological roles, usually counterbalancing the classical effects exerted by Ang II.
Objective: We aim to provide an overview of effects elicited by the RAS, especially Ang-(1-7), in the brain. We also aim to discuss the therapeutic potential for neuropsychiatric disorders for the modulation of RAS.
Method: We carried out an extensive literature search in PubMed central.
Results: Within the brain, Ang-(1-7) contributes to the regulation of blood pressure by acting at regions that control cardiovascular functions. In contrast with Ang II, Ang-(1-7) improves baroreflex sensitivity and plays an inhibitory role in hypothalamic noradrenergic neurotransmission. Ang-(1-7) not only exerts effects related to blood pressure regulation, but also acts as a neuroprotective component of the RAS, for instance, by reducing cerebral infarct size, inflammation, oxidative stress and neuronal apoptosis.
Conclusion: Pre-clinical evidence supports a relevant role for ACE2/Ang-(1-7)/Mas receptor axis in several neuropsychiatric conditions, including stress-related and mood disorders, cerebrovascular ischemic and hemorrhagic lesions and neurodegenerative diseases. However, very few data are available regarding the ACE2/Ang-(1-7)/Mas receptor axis in human CNS.
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Cite this article as:
RAS in the Central Nervous System: Potential Role in Neuropsychiatric Disorders, Current Medicinal Chemistry 2018; 25 (28) . https://dx.doi.org/10.2174/0929867325666180226102358
DOI https://dx.doi.org/10.2174/0929867325666180226102358 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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