Innovative Therapeutic Potential of Cannabinoid Receptors as  Targets in Alzheimer’s Disease and Less Well-Known Diseases

doi:10.2174/0929867325666180226095132
摘要

在1990年代初发现了大麻素受体，1990年克隆了CB1，1993年克隆了CB2，只有通过能够与之结合的内源性配体的存在，才能证明选择性和强效大麻仿制药的有效性。因此，第一个大麻素受体（CB1）的鉴定和克隆导致两年后第一个内源性大麻素花生四烯酰乙醇酰胺（AEA）的分离和鉴定，并随后鉴定了称为脂肪酸酯2的脂质递质家族 -花生四烯酰基甘油（2-AG）。内源性大麻素系统是一个复杂的信号系统，包括跨膜内源性大麻素受体，其内源性配体（内源性大麻素），特定的摄取机制以及与它们的生物合成和降解有关的酶系统。内源性大麻素系统已牵涉到中枢神经系统和周围神经系统的多种生物过程中，包括记忆，学习，神经元发育，压力和情绪，食物摄入，能量调节，外周代谢和激素平衡调节通过内分泌系统。在这种情况下，本文将回顾有关大麻素受体作为阿尔茨海默氏病和其他较不为人所知的疾病（包括多发性硬化症，骨骼代谢和脆性X综合征）的靶标的治疗潜力的最新知识。将通过研究大麻素激动剂作为单一药物和多靶点药物（强调CB2受体激动剂）来解决治疗应用。
关键词: 阿尔茨海默氏病，CB2激动剂，内源性大麻素系统（eCS），骨骼疾病，自闭症，心血管疾病。
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DOI https://dx.doi.org/10.2174/0929867325666180226095132	Print ISSN 0929-8673
Publisher Name Bentham Science Publisher	Online ISSN 1875-533X
当代药物化学

大麻素受体作为阿尔茨海默氏病和鲜为人知疾病的靶标的创新治疗潜力

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当代药物化学

大麻素受体作为阿尔茨海默氏病和鲜为人知疾病的靶标的创新治疗潜力

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