摘要
背景:GWAS鉴定了几种SNP与2型糖尿病的关系,这与胰腺β细胞生理有一定的关系。 目的:研究TCF7L2、KCNJ 11、CDKN2A、CDKAL 1、IGF2BP2、SLC30A8和KCNQ 1的危险等位基因在磺脲类药物反应中的作用。 方法:对209例初诊的患者进行前瞻性研究,采用单纯的T2D治疗。个体开始使用格列本脲单药治疗,随访12次。艾克斯。基因分型采用PCR-RFLP和TETRA-ARM PCR,DNA测序证实. 结果:在单因素回归分析中,KCNJ 11(Rs 5219)仅是格列本脲治疗失败的预测因子。 结论:KCNJ 11基因可能在格列本脲改变反应中起重要作用。
关键词: 磺脲类、格列苯脲、基因组广泛相关研究(GWAS)、2型糖尿病、T-ARMSPCR、KCNJ 11基因。
Current Molecular Medicine
Title:Genetic Variants Identified from GWAS for Predisposition to Type 2 Diabetes Predict Sulfonylurea Drug Response
Volume: 17 Issue: 8
关键词: 磺脲类、格列苯脲、基因组广泛相关研究(GWAS)、2型糖尿病、T-ARMSPCR、KCNJ 11基因。
摘要: Background: Several SNPs were identified through GWAS for their association with type 2 diabetes which has implications to pancreatic β-cell physiology.
Objective: We aimed to study the role of risk alleles of TCF7L2, KCNJ11, CDKN2A, CDKAL1, IGF2BP2, SLC30A8 and KCNQ1 along with pharmacokinetic variants in response to sulfonylureas.
Method: We performed a prospective study on 209 newly diagnosed subjects; treatment naive T2D subjects were recruited. Individuals were started with glibenclamide monotherapy and followed-up for 12 weeks. Genotyping was done, using PCR-RFLP and TETRA-ARMS PCR and confirmed by DNA sequencing.
Results: In univariate regression analysis, KCNJ11 (rs5219) was only the predictor for glibenclamide treatment failure.
Conclusion: The present data suggests a possible role of KCNJ11 gene in altered response to glibenclamide.
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Cite this article as:
Genetic Variants Identified from GWAS for Predisposition to Type 2 Diabetes Predict Sulfonylurea Drug Response, Current Molecular Medicine 2017; 17 (8) . https://dx.doi.org/10.2174/1566524018666180222122653
DOI https://dx.doi.org/10.2174/1566524018666180222122653 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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