摘要
氧化/硝化损伤是导致肺癌发生的重要因素之一。一氧化氮(NO)自由基通过酪氨酸硝化等化学修饰参与肺癌的发生和转移。NO介导的蛋白质硝化是肺癌中一种重要的分子事件,它是在酪氨酸残基的酚环第3位上添加硝基(-NO2)基团的产物。硝化参与多种生物学过程,包括信号转导、蛋白质降解、能量代谢、线粒体功能障碍、酶失活、免疫原反应、凋亡和细胞死亡。本文综述了NO及其衍生物与肺癌的关系、酪氨酸硝化在肺癌中的形成和作用、肺癌与其他炎症性肺部疾病蛋白硝化的差异、蛋白质硝化和硝基蛋白组学在肺癌中的研究现状,以及更好地理解肺癌发生、生物标志物发现、新的诊断、预后监测和治疗靶点的前景。
关键词: 肺癌,酪氨酸硝化,硝基蛋白质组学,质谱,系统生物学,结构生物学。
Current Medicinal Chemistry
Title:Protein Tyrosine Nitration in Lung Cancer: Current Research Status and Future Perspectives
Volume: 25 Issue: 29
关键词: 肺癌,酪氨酸硝化,硝基蛋白质组学,质谱,系统生物学,结构生物学。
摘要: Oxidative/nitrative damage is a crucial element among the complex factors that contribute to lung carcinogenesis. Nitric oxide (NO) free radicals, through chemical modifications such as tyrosine nitration, are significantly involved in lung carcinogenesis and metastasis. NO-mediated protein nitration, which is the addition of the nitro group (–NO2) to position 3 of the phenolic ring of a tyrosine residue, is an important molecular event in lung cancer, and has been studied with mass spectrometry. Nitration is involved in multiple biological processes, including signal transduction, protein degradation, energy metabolism, mitochondrial dysfunction, enzyme inactivation, immunogenic response, apoptosis, and cell death. This article reviews the relationship of NO and its derivates and lung cancer, formation and roles of tyrosine nitration in lung cancer, differences of protein nitration between lung cancer and other inflammatory pulmonary diseases, current status of protein nitration and nitroproteomics in lung cancer, and future perspectives to achieve a better understanding of lung carcinogenesis, for biomarker discovery; and for new diagnostic and prognostic monitoring, and therapeutic targets.
Export Options
About this article
Cite this article as:
Protein Tyrosine Nitration in Lung Cancer: Current Research Status and Future Perspectives, Current Medicinal Chemistry 2018; 25 (29) . https://dx.doi.org/10.2174/0929867325666180221140745
DOI https://dx.doi.org/10.2174/0929867325666180221140745 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Current Antioxidant Molecular Therapies for Oxidative Stress-Related Ailments
Current Gene Therapy Anti-HER2 Cancer Therapy and Cardiotoxicity
Current Pharmaceutical Design Synthesis and In Vitro Antitumor Activity of Novel Fluorine Containing Pyrazoles and Pyrazolines
Letters in Drug Design & Discovery Hepatocyte Growth Factor Signaling in Cancer Metastasis
Current Signal Transduction Therapy MicroRNAs in Glioblastoma: Role in Pathogenesis and Opportunities for Targeted Therapies
CNS & Neurological Disorders - Drug Targets Expression of NRP-1 and NRP-2 in Endometrial Cancer
Current Pharmaceutical Biotechnology Omega-3 Polyunsaturated Fatty Acids and Cancer
Anti-Cancer Agents in Medicinal Chemistry Dual Drug Conjugate Loaded Nanoparticles for the Treatment of Cancer
Current Drug Delivery Basis for Resistance to Imatinib in 16 BCR-ABL Mutants as Determined Using Molecular Dynamics
Recent Patents on Anti-Cancer Drug Discovery Anti-Angiogenic Therapy as a Cancer Treatment Paradigm
Current Medicinal Chemistry - Anti-Cancer Agents Computational Analysis of miRNA and their Gene Targets Significantly Involved in Colorectal Cancer Progression
MicroRNA MicroRNAs and Targeted Therapies in Non-small Cell Lung Cancer: Minireview
Anti-Cancer Agents in Medicinal Chemistry Toxicity of Biodegradable Nanoscale Preparations
Current Drug Metabolism Immobilization Techniques Applied to the Development of Biocatalysts for the Synthesis of Nucleoside Analogue Derivatives
Current Pharmaceutical Design Palladium (II) Complex Enhances ROS-Dependent Apoptotic Effects <i>via</i> Autophagy Inhibition and Disruption of Multiple Signaling Pathways in Colorectal Cancer Cells
Anti-Cancer Agents in Medicinal Chemistry Role of the Retinoblastoma Tumor Suppressor in the Maintenance of Genome Integrity
Current Molecular Medicine HGF Airway Over-expression Leads to Enhanced Pulmonary Vascularization without Induction of VEGF
Current Angiogenesis (Discontinued) Folate Targeted Solid Lipid Nanoparticles of Simvastatin for Enhanced Cytotoxic Effects of Doxorubicin in Chronic Myeloid Leukemia
Current Nanoscience Nitroxyl (HNO): A Possible Strategy for Fighting Cancer
Current Topics in Medicinal Chemistry Recent Progress in Clinical Development of Therapeutic Antibodies Targeting Glycan-Binding Proteins
Current Drug Targets