摘要
肾移植后移植物丢失仍是一个严重的临床问题。移植物丢失的分子机制是一个复杂的过程,包括T细胞和/或B细胞的激活,炎症反应,自噬和凋亡。由于这些途径参与了肾移植排斥反应中的免疫反应,因此应用基因干扰抑制特定途径可能会产生效果。VE靶向基因治疗方法。最近的研究已经成功地尝试使用基因疗法来靶向免疫移植过程中免疫应答的关键分子。这个策略有P沉默与多种疾病相关的靶基因,包括器官移植后引起同种异体移植丢失的基因。在这次检讨中,我们讨论了基因治疗在肾移植中的应用是基于肾脏疾病与参与其潜在机制的基因之间的已知联系。分子免疫反应和炎症损伤是未来肾移植临床治疗的潜在靶点。
关键词: 基因治疗,肾移植,RNAi,siRNA,ESRD,下腔静脉。
Current Gene Therapy
Title:Gene Therapy in Kidney Transplantation: Evidence of Efficacy and Future Directions
Volume: 17 Issue: 6
关键词: 基因治疗,肾移植,RNAi,siRNA,ESRD,下腔静脉。
摘要: Allograft loss remains a severe clinical problem after kidney transplantation. The molecular mechanism of graft loss is a complex process involving T and/or B cell activation, inflammation responses, autophagy and apoptosis. Since these pathways are involved in immune responses in kidney transplant rejection, application of genetic interference to inhibit specific pathways could present an effective targeted gene therapy method. Recent studies have successfully attempted to use gene therapy to target the key molecules involved in immune responses during transplantation. This strategy has the potential to silence target genes associated with a variety of diseases, including those that trigger allograft loss following organ transplantation. In this review, we have discussed evidence of the clinical applicability of gene therapy in kidney transplantation based on known associations between kidney diseases and genes participating in the underlying mechanisms. The molecules contributing to immune responses and inflammatory injury are further highlighted as potential targets in future clinical therapy for renal transplantation.
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Gene Therapy in Kidney Transplantation: Evidence of Efficacy and Future Directions, Current Gene Therapy 2017; 17 (6) . https://dx.doi.org/10.2174/1566523218666180214095606
DOI https://dx.doi.org/10.2174/1566523218666180214095606 |
Print ISSN 1566-5232 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5631 |
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