Abstract
Genes which encode inflammatory cytokines are subject to polymorphisms in their regulatory regions that may effect both the level and ratio of cytokines produced in response to exogenous stimuli. These variant alleles are observed in a large percent of the population and are often associated with increased or decreased susceptibility or severity (modifiers) to infectious, immune or inflammatory diseases. Environmental factors can also play either a direct (i.e., causative factor) or indirect (modifying factor) role in these diseases. Thus, it would follow that gene-environment interactions would effect the expression and / or progression of the disease. In the present review, the concept that some of the common allelic variants found in cytokine genes represent modifying factors in chronic inflammatory diseases associated with occupational exposure is discussed.
Keywords: single nucleotide polymorphisms, cytokine network, chronic inflammatory diseases, occupational diseases, cytokine polymorphisms
Current Molecular Medicine
Title: Cytokine Polymorphisms in Chronic Inflammatory Diseases with Reference to Occupational Diseases
Volume: 3 Issue: 1
Author(s): Berran Yucesoy, Michael L. Kashon and Michael I. Luster
Affiliation:
Keywords: single nucleotide polymorphisms, cytokine network, chronic inflammatory diseases, occupational diseases, cytokine polymorphisms
Abstract: Genes which encode inflammatory cytokines are subject to polymorphisms in their regulatory regions that may effect both the level and ratio of cytokines produced in response to exogenous stimuli. These variant alleles are observed in a large percent of the population and are often associated with increased or decreased susceptibility or severity (modifiers) to infectious, immune or inflammatory diseases. Environmental factors can also play either a direct (i.e., causative factor) or indirect (modifying factor) role in these diseases. Thus, it would follow that gene-environment interactions would effect the expression and / or progression of the disease. In the present review, the concept that some of the common allelic variants found in cytokine genes represent modifying factors in chronic inflammatory diseases associated with occupational exposure is discussed.
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Cite this article as:
Yucesoy Berran, Kashon L. Michael and Luster I. Michael, Cytokine Polymorphisms in Chronic Inflammatory Diseases with Reference to Occupational Diseases, Current Molecular Medicine 2003; 3 (1) . https://dx.doi.org/10.2174/1566524033361582
DOI https://dx.doi.org/10.2174/1566524033361582 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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