Direct and Facile Synthesis of Primary Amides from Carboxylic Acids via Acyl Isocyanate Intermediates Using Mukaiyama Reagent

Roya        Azadi; Zahra         Motamedpoor

doi:10.2174/1570178615666180212152643

Abstract

A very simple and efficient procedure for the preparation of primary amides is described from carboxylic acids using Mukaiyama reagent/KNCO in aqueous acetonitrile. Availability of the reagents, simplicity, and easy workup of the reaction crude make this method attractive for organic chemists.

Keywords: 2-Chloro-1-methylpyridinium iodide, acyl isocyanate, amide, carboxylic acid, mukaiyama reagent.

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Letters in Organic Chemistry

Title:Direct and Facile Synthesis of Primary Amides from Carboxylic Acids via Acyl Isocyanate Intermediates Using Mukaiyama Reagent

Volume: 15 Issue: 9

Author(s): Roya Azadi*Zahra Motamedpoor

Affiliation:

Chemistry Department, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz,Iran

Keywords: 2-Chloro-1-methylpyridinium iodide, acyl isocyanate, amide, carboxylic acid, mukaiyama reagent.

Abstract: A very simple and efficient procedure for the preparation of primary amides is described from carboxylic acids using Mukaiyama reagent/KNCO in aqueous acetonitrile. Availability of the reagents, simplicity, and easy workup of the reaction crude make this method attractive for organic chemists.

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Azadi Roya *, Motamedpoor Zahra , Direct and Facile Synthesis of Primary Amides from Carboxylic Acids via Acyl Isocyanate Intermediates Using Mukaiyama Reagent, Letters in Organic Chemistry 2018; 15 (9) . https://dx.doi.org/10.2174/1570178615666180212152643

DOI https://dx.doi.org/10.2174/1570178615666180212152643	Print ISSN 1570-1786
Publisher Name Bentham Science Publisher	Online ISSN 1875-6255