摘要
背景:神经退行性疾病包括一组迄今尚未治疗的疾病。干细胞为基础的治疗提供了很大的希望和承诺。然而,干细胞移植与某些缺点有关,如移植细胞的定向迁移,植入和存活较差。 材料和方法:外来体,一种由包括干细胞在内的所有细胞类型释放的细胞外囊泡,为干细胞移植提供了一种替代方法。外来体携带大量的生物分子,并且涉及在受损组织的修复/再生中表现出显着的益处。因此,外来体提供替代的治疗方法作为细胞移植的替代物。为了将外来体用于治疗目的,必须评估合适的传代次数和剂量以避免可能的细胞毒性作用。在此,我们从大鼠骨髓间充质干细胞(BM-MSC)的不同代外来体中分离了外来体,并且在体外兴奋毒性模型中分析了BM-MSC外泌体的神经保护潜力。 结果:我们的研究结果表明从大鼠BM-MSC早期分离的外泌体展现出更有效的神经保护潜力,而不是晚期传代衍生的外来体。此外,外泌体的神经保护功效是剂量依赖性的。即发现较低剂量的外来体是神经保护的,而较高剂量的外来体(来自后来的传代)被发现对神经元有害。早期通过外源体通过抗凋亡,抗坏死和抗氧化机制保护神经元。 结论:我们的研究表明,成体干细胞衍生的外泌体可能是一种潜在的治疗剂,赋予神经退行性疾病如阿尔茨海默病的神经保护作用。
关键词: 海马,骨髓,间充质,外泌体,神经变性,神经保护。
Current Gene Therapy
Title:Dosage and Passage Dependent Neuroprotective Effects of Exosomes Derived from Rat Bone Marrow Mesenchymal Stem Cells: An In Vitro Analysis
Volume: 17 Issue: 5
关键词: 海马,骨髓,间充质,外泌体,神经变性,神经保护。
摘要: Background: Neurodegenerative diseases comprise a group of disorders for which no treatment is available till date. Stem cell based therapy offers great hope and promise. However, stem cell transplantation is associated with certain disadvantages like poor targeted migration, engraftment and survival of the transplanted cells.
Material & Method: Exosomes, a type of extracellular membrane vesicle released by all cell types including stem cells, offer an alternative to stem cell transplantation. Exosome carry a wide array of biomolecules and are implicated in exhibiting substantial benefits in the repair/regeneration of the injured tissue. Thus, exosomes offer an alternative therapeutic approach as a substitute of cell transplantation. In order to utilize exosomes for therapeutic purpose, it is essential to evaluate the appropriate passage number and the dosage to avoid possible cytotoxic effects. Here, we isolated exosomes from different passages of rat bone marrow mesenchymal stem cells (BM-MSC) and analysed the neuroprotective potential of BM-MSC exosomes in an in vitro model of excitotoxicity.
Result: Our results demonstrated that the exosomes isolated from early passage of rat BM-MSC exhibited more efficient neuroprotective potential as opposed to later passages derived exosomes. Furthermore, the neuroprotective efficacy of exosome is dosage dependent. i.e. the lower dosage of exosomes was found to be neuroprotective, whereas higher dosage of exosomes (from later passages) was found to be detrimental to neurons. The early passage derived exosomes protected neurons through anti-apoptotic, anti-necrotic and anti-oxidant mechanisms.
Conclusion: Our study suggests that adult stem cells derived exosomes could be a potential therapeutic agent to confer neuroprotection in neurodegenerative diseases like Alzheimer's disease.
Export Options
About this article
Cite this article as:
Dosage and Passage Dependent Neuroprotective Effects of Exosomes Derived from Rat Bone Marrow Mesenchymal Stem Cells: An In Vitro Analysis, Current Gene Therapy 2017; 17 (5) . https://dx.doi.org/10.2174/1566523218666180125091952
DOI https://dx.doi.org/10.2174/1566523218666180125091952 |
Print ISSN 1566-5232 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5631 |
Call for Papers in Thematic Issues
Programmed Cell Death Genes in Oncology: Pioneering Therapeutic and Diagnostic Frontiers (BMS-CGT-2024-HT-45)
Programmed Cell Death (PCD) is recognized as a pivotal biological mechanism with far-reaching effects in the realm of cancer therapy. This complex process encompasses a variety of cell death modalities, including apoptosis, autophagic cell death, pyroptosis, and ferroptosis, each of which contributes to the intricate landscape of cancer development and ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
New Tuberculosis Drugs in Development
Current Topics in Medicinal Chemistry Serotonergic and Behavioral Responses to Stress with Tryptophan in Rats
Current Psychopharmacology Population Diversity and its Relationship with Infectious and Tumor Diseases
Current Immunology Reviews (Discontinued) Editorial (Alcohol, Drugs, and Diving: Implications for Health and Fitness to Dive)
Current Drug Abuse Reviews The Role of Type 2 Fibroblast Growth Factor in Periodontal Therapy
Current Drug Targets Effects of Brain IKKβ Gene Silencing by Small Interfering RNA on P-Glycoprotein Expression and Brain Damage in the Rat Kainic Acid-Induced Seizure Model
CNS & Neurological Disorders - Drug Targets Diagnosis of Systemic Lupus Erythematosus in an Unusual Presentation: What a Primary Care Physician Should Know
Current Rheumatology Reviews Oligonucleotide Aptamers for Glioma Targeting: An Update
Central Nervous System Agents in Medicinal Chemistry Passive Smoking, Endothelial Dysfunction and Related Markers in Healthy Individuals: An Update
Current Hypertension Reviews Levodopa in Parkinson’s Disease: Current Status and Future Developments
Current Neuropharmacology Proinflammatory Cytokines and Sickness Behavior in Rheumatic Diseases
Current Pharmaceutical Design Acute Effects of a Single, Oral dose of d9-tetrahydrocannabinol (THC) and Cannabidiol (CBD) Administration in Healthy Volunteers
Current Pharmaceutical Design Long-Term Protective Effects of Methamphetamine Preconditioning Against Single-Day Methamphetamine Toxic Challenges
Current Neuropharmacology Editorial [Hot Topic: G-Protein-Coupled Receptors (GPCRs) and Drug Discovery (Guest Editor: Luca Gentilucci)]
Current Drug Targets Pharmacokinetic Study of Four Components in Rat Plasma After Oral Administration of Guanmaitong Granule by UPLC-MS/MS
Current Pharmaceutical Analysis Established and In-trial GPCR Families in Clinical Trials: A Review for Target Selection
Current Drug Targets Cardiovascular Disease Risk Among the Poor and Homeless – What We Know So Far
Current Cardiology Reviews Magnetic Nanoparticles Utilized in Hemodialysis for the Treatment of Hyperhomocysteinemia:The New Challenge of Nanobiotechnology
Current Nanoscience Genetic Lipodystrophies: Models for Insulin Resistance
Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents Clomiphene Citrate, Metformin or Aromatase Inhibitors for Anovulatory Infertility in Women with Polycystic Ovary Syndrome (PCOS): A Systematic Review of Meta-analyses and Randomized Controlled Trials
Clinical Immunology, Endocrine & Metabolic Drugs (Discontinued)