The Acidophilic Kinases PLK2 and PLK3: Structure, Substrate Targeting and Inhibition

Title:The Acidophilic Kinases PLK2 and PLK3: Structure, Substrate Targeting and Inhibition

Volume: 19 Issue: 8

Author(s): Giorgio Cozza and Mauro Salvi*

Affiliation:

• Department of Biomedical Sciences, University of Padova, Via U. Bassi 58/B, 35121 Padova,Italy

Keywords: Acidophilic kinases, clinical trials, inhibitors, Polo-like kinases, PLK2, PLK3.

Abstract: PLK2 and PLK3 are two closely related acidophilic kinases belonging to the Polo-like kinases (PLKs), a family of five members in mammals with a central role in cell cycle and related events. PLK1 is the most investigated enzyme from both physiological and pharmaceutical points of view, however, several specialized cellular functions of PLK2 and PLK3 have been recently discovered paving the way to deepened studies on their biological roles and their feasible selection as future therapeutic targets. Our review aims to provide a summarized view of the current knowledge regarding PLK2 and PLK3 kinases, including substrate specificity and signaling pathways directly affected by these kinases. Finally, an overview of PLK2 and PLK3 pharmacological regulation and perspectives in future achievements are proposed.

Cite this article as:

Cozza Giorgio and Salvi Mauro *, The Acidophilic Kinases PLK2 and PLK3: Structure, Substrate Targeting and Inhibition, Current Protein & Peptide Science 2018; 19 (8) . https://dx.doi.org/10.2174/1389203719666180124095405

DOI https://dx.doi.org/10.2174/1389203719666180124095405	Print ISSN 1389-2037
Publisher Name Bentham Science Publisher	Online ISSN 1875-5550