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Review Article

AMPK / mTOR调节剂在急性髓细胞白血病治疗中的作用

卷 26, 期 12, 2019

页: [2208 - 2229] 页: 22

弟呕挨: 10.2174/0929867325666180117105522

价格: $65

摘要

全反式维甲酸对急性早幼粒细胞白血病的分化治疗是急性髓性白血病（AML）最成功的药物治疗方法。 大量研究表明，抑制雷帕霉素机械靶标（mTOR）和激活AMP激酶（AMPK）的药物在促进分化和阻断AML增殖方面具有有益作用。 大多数这些药物已经用于其他目的; 作为免疫抑制剂的rapalogs，作为口服抗糖尿病药的双胍类和作为运动模拟物的5-氨基-4-咪唑甲酰胺核糖核苷（AICAr，acadesine）。 尽管大多数这些药理学调节剂已被广泛使用数十年，但其作用机制仅部分被理解。 在这篇综述中，我们总结了AMPK和mTOR在血液系统恶性肿瘤中的作用，并讨论了药理学调节剂在白血病细胞增殖和分化中的可能作用。

关键词: AML，AMPK，mTOR，雷帕霉素，二甲双胍，AICAR，分化。

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