摘要
不同肽的病理积累是阿尔茨海默病(AD)等多种神经退行性变过程的共同基础。AD的特点是淀粉样沉积,可能导致al。神经传递、炎症机制的激活、神经元死亡和脑萎缩等。在体内诊断是有挑战性的,因为标准主要依赖于临床表现,WHI。CH仅在疾病晚期才明显。虽然目前AD可以通过尸检组织病理学检查确诊,但活体成像可以提高临床医生的能力。o在早期阶段识别AD。在这方面,用正电子发射断层扫描(PET)检测脑淀粉样斑可能会提高诊断水平,并能迅速启动有效的治疗。许多用于AD特异性病理修饰的PET成像探针已经被开发出来,并被证明在体内检测淀粉样沉积是有效的。我们在这里回顾一下当前的知识PET显像在淀粉样沉积检测中的应用及在AD诊断中的应用。
关键词: 淀粉样蛋白,阿尔茨海默病,轻度认知障碍,PET,18F-Florbetaben,18F-Florbetapir,18F-Flutemetamol,11C-PIB.
Current Medicinal Chemistry
Title:Radiotracers for Amyloid Imaging in Neurodegenerative Disease: State-of-the-Art and Novel Concepts
Volume: 25 Issue: 26
关键词: 淀粉样蛋白,阿尔茨海默病,轻度认知障碍,PET,18F-Florbetaben,18F-Florbetapir,18F-Flutemetamol,11C-PIB.
摘要: The pathological accumulation of different peptides is the common base of many neurodegenerative processes, such as Alzheimer’s disease (AD). AD is characterized by amyloid deposits which may cause alterations in neurotransmission, activation of inflammatory mechanisms, neuronal death and cerebral atrophy. Diagnosis in vivo is challenging as the criteria rely mainly on clinical manifestations, which become evident only in a late stage of the disease. While AD can currently be definitively confirmed by postmortem histopathologic examination, in vivo imaging may improve the clinician's ability to identify AD at the earliest stage.
In this regard, the detection of cerebral amyloid plaques with positron emission tomography (PET) is likely to improve diagnosis and allow for a prompt start of an effective therapy. Many PET imaging probes for AD-specific pathological modifications have been developed and proved effective in detecting amyloid deposits in vivo. We here review the current knowledge on PET imaging in the detection of amyloid deposits and their application in the diagnosis of AD.
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Cite this article as:
Radiotracers for Amyloid Imaging in Neurodegenerative Disease: State-of-the-Art and Novel Concepts, Current Medicinal Chemistry 2018; 25 (26) . https://dx.doi.org/10.2174/0929867325666180117094704
DOI https://dx.doi.org/10.2174/0929867325666180117094704 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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