Abstract
Macrophages are professional scavengers of apoptotic and necrotic cells, and hence constantly take up self antigens. Paradoxically, macrophages are also professional antigen-presenting cells, which would seem to invite autoimmune disorders. Moreover, macrophages are effector cells in the tissue-destruction phase of autoimmune disorders, where they encounter additional self antigens in the stimulatory context of chronic inflammation. This review examines the array of immunosuppressive mechanisms which may help macrophages suppress unwanted T cell responses, and considers the consequences of a breakdown in these negativeregulatory systems in autoimmunity.
Keywords: macrophages, immune tolerance, self tolerance, autoimmunity, t cells, indoleamine 2, 3-dioxygenase, tryptophan
Current Pharmaceutical Design
Title: Macrophages and the Regulation of Self-Reactive T Cells
Volume: 9 Issue: 3
Author(s): David H. Munn and Andrew L. Mellor
Affiliation:
Keywords: macrophages, immune tolerance, self tolerance, autoimmunity, t cells, indoleamine 2, 3-dioxygenase, tryptophan
Abstract: Macrophages are professional scavengers of apoptotic and necrotic cells, and hence constantly take up self antigens. Paradoxically, macrophages are also professional antigen-presenting cells, which would seem to invite autoimmune disorders. Moreover, macrophages are effector cells in the tissue-destruction phase of autoimmune disorders, where they encounter additional self antigens in the stimulatory context of chronic inflammation. This review examines the array of immunosuppressive mechanisms which may help macrophages suppress unwanted T cell responses, and considers the consequences of a breakdown in these negativeregulatory systems in autoimmunity.
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Cite this article as:
Munn H. David and Mellor L. Andrew, Macrophages and the Regulation of Self-Reactive T Cells, Current Pharmaceutical Design 2003; 9 (3) . https://dx.doi.org/10.2174/1381612033392026
DOI https://dx.doi.org/10.2174/1381612033392026 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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