摘要
背景:阿尔茨海默病(AD)是一种神经变性疾病,其逐渐诱导老年人的认知缺陷,并且通常在AD中观察到工作记忆障碍。淀粉状蛋白β肽(Aβ)是AD认知功能障碍的致病因素。伽玛振荡已被认为在包括工作记忆在内的各种认知功能中发挥重要作用。先前的研究报道Aβ诱导工作记忆中的γ振荡功能障碍。 目的:尽管重复性经颅磁刺激(rTMS)代表了一种无创刺激诱导皮层活动和兴奋性改变的技术,并且已被接受用于增加大脑兴奋性和调节认知行为,但是rTMS是否可以保留Aβ诱导的γ振荡功能障碍工作记忆仍不清楚。本研究旨在探讨rTMS对工作记忆中Aβ诱导的γ振荡功能障碍的影响。 方法:本研究调查rTMS调制的伽玛振荡Aβ1-42诱导的记忆缺陷。成年SD大鼠分为四组:Aβ,Con,Aβ+ rTMS和Con + rTMS。从大鼠内侧前额叶皮层记录16通道局部场电位(LFP),而大鼠进行Y-迷宫工作记忆任务。通过一致性测量LFP中的伽马振荡。 结果:结果显示,rTMS改善了Aβ注射受试者的行为表现和增强的γ振荡。 结论:这些结果表明,rTMS可能在工作记忆中保留Aβ诱导的γ振荡功能障碍,从而导致工作记忆的潜在益处。
关键词: 重复经颅磁刺激(rTMS),淀粉样β肽(Aβ),工作记忆,局部场电位(LFPs),γ振荡,大鼠
Current Alzheimer Research
Title:Repetitive Transcranial Magnetic Stimulation Reverses Aβ1–42-induced Dysfunction in Gamma Oscillation during Working Memory
Volume: 15 Issue: 6
关键词: 重复经颅磁刺激(rTMS),淀粉样β肽(Aβ),工作记忆,局部场电位(LFPs),γ振荡,大鼠
摘要: Background: Alzheimer's disease (AD) is a neurodegenerative disease that gradually induces cognitive deficits in the elderly and working memory impairment is typically observed in AD. Amyloid-β peptide (Aβ) is a causative factor for the cognitive impairments in AD. Gamma oscillations have been recognized to play important roles in various cognitive functions including working memory. Previous study reported that Aβ induces gamma oscillation dysfunction in working memory.
Objective: Although repetitive transcranial magnetic stimulation (rTMS) represents a technique for noninvasive stimulation to induce cortical activity and excitability changes and has been accepted for increasing brain excitability and regulating cognitive behavior, the question whether rTMS can reserve the Aβ-induced gamma oscillation dysfunction during working memory remains unclear. The present study aims to investigate the effect of rTMS to the Aβ-induced gamma oscillation dysfunction during working memory.
Method: The present study investigates the rTMS-modulated gamma oscillation in Aβ1-42-induced memory deficit. Adult SD rats were divided into four groups: Aβ, Con, Aβ+rTMS and Con+rTMS. 16-channel local field potentials (LFPs) were recorded from rat medial prefrontal cortex while the rats performed a Y-maze working memory task. Gamma oscillation among LFPs was measured by coherence.
Results: The results show that rTMS improved the behavior performance and enhanced gamma oscillation for the Aβ-injected subjects.
Conclusion: These results indicate that rTMS may reserve the Aβ-induced dysfunction in gamma oscillation during working memory and thus result in potential benefits for working memory.
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Cite this article as:
Repetitive Transcranial Magnetic Stimulation Reverses Aβ1–42-induced Dysfunction in Gamma Oscillation during Working Memory, Current Alzheimer Research 2018; 15 (6) . https://dx.doi.org/10.2174/1567205015666180110114050
DOI https://dx.doi.org/10.2174/1567205015666180110114050 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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