An Overview of Discovery of Thiazole Containing Heterocycles as Potent GSK-3β Inhibitors

Title:An Overview of Discovery of Thiazole Containing Heterocycles as Potent GSK-3β Inhibitors

Volume: 15 Issue: 3

Author(s): Deepika Sharma*, Anjleena Malhotra and Ranju Bansal

Affiliation:

• Chandigarh College of Pharmacy, Landran, Mohali-140307, Punjab,India

Keywords: Thiazole, GSK-3β, GSK-3β inhibitor, heterocycles, protein kinases, enzyme.

Abstract: Glycogen synthase kinase-3 (GSK-3) is a multifunctional serine/threonine (ser/thr) kinase that was originally identified as a regulator of glycogen metabolism and coupled with insulin signaling. Due to multifunctionality of this enzyme, it is found to play an important role in the onset and progression of various human diseases. Thiazole nucleus has received special attention by medicinal chemists because of its wide therapeutic potential. The objective of this review is to cover all the aspects of GSK-3β enzyme including its clinical implications, types of inhibitors with special reference to thiazole as GSK-3β inhibitor. Literature search was performed using Pubmed/Medline and Google Scholar to search for articles published in English language.

Cite this article as:

Sharma Deepika*, Malhotra Anjleena and Bansal Ranju , An Overview of Discovery of Thiazole Containing Heterocycles as Potent GSK-3β Inhibitors, Current Drug Discovery Technologies 2018; 15 (3) . https://dx.doi.org/10.2174/1570163815666180104120857