摘要
背景:腹主动脉瘤(AAA)是一种涉及主动脉节段扩张和破裂的常见疾病,死亡率高。目前,AAA的治疗选择仅限于外科修复以防止更严重的损伤。非手术治疗,尤其是药物治疗,对于AAA的治疗是缺乏的。 目的:我们回顾了基础和临床研究,并讨论了目前在发展药物治疗,减少AAA进展的挑战。 结果:利用AAA进展的动物模型和人AAA外植体培养的研究已经确定了几种预防AAA生长的潜在靶点,但没有临床研究能令人信服地证实任何药物治疗对抑制AAA生长的作用,因此目前尚无相关的治疗药物可以降低AAA疾病进程和损害风险。 结论:本综述确定了该领域需要解决的问题,并讨论了必须克服的挑战,以便开发有效的药物治疗以减少AAA进展。
关键词: 腹主动脉瘤,药物治疗,医学治疗,进展,动物研究,临床研究,实践指南,未来展望。
图形摘要
Current Drug Targets
Title:Current Status and Perspectives on Pharmacologic Therapy for Abdominal Aortic Aneurysm
Volume: 19 Issue: 11
关键词: 腹主动脉瘤,药物治疗,医学治疗,进展,动物研究,临床研究,实践指南,未来展望。
摘要: Background: Abdominal aortic aneurysm (AAA), a common disease involving the segmental expansion and rupture of the aorta, has a high mortality rate. Therapeutic options for AAA are currently limited to surgical repair to prevent catastrophic rupture. Non-surgical approaches, particularly pharmacotherapy, are lacking for the treatment of AAA.
Objective: We review both basic and clinical studies and discuss the current challenges to developing medical therapy that reduces AAA progression.
Results: Studies using animal models of AAA progression and human AAA explant cultures have identified several potential targets for preventing AAA growth. However, no clinical studies have convincingly confirmed the efficacy of any pharmacologic treatment against the growth of AAA. Thus, there is as yet no strong recommendation regarding pharmacotherapy to reduce the risk of AAA progression and rupture.
Conclusion: This review identifies concerns that need to be addressed for the field to progress and discusses the challenges that must be overcome in order to develop effective pharmacotherapy to reduce AAA progression in the future.
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Cite this article as:
Current Status and Perspectives on Pharmacologic Therapy for Abdominal Aortic Aneurysm, Current Drug Targets 2018; 19 (11) . https://dx.doi.org/10.2174/1389450119666171227223331
DOI https://dx.doi.org/10.2174/1389450119666171227223331 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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