Functionalized Ionic Liquids as New Supports for Peptide Coupling and Traceless Catalyzed Carbon-Carbon Coupling Reactions

Title: Functionalized Ionic Liquids as New Supports for Peptide Coupling and Traceless Catalyzed Carbon-Carbon Coupling Reactions

Volume: 9 Issue: 3

Author(s): Fabien Bonnette, Zoia Mincheva and Olivier Lavastre

Affiliation:

Keywords: Ionic liquids support, coupling reactions

Abstract: A new strategy to obtain pure ionic liquid support with a high loading (3 mmol/g) of primary amino groups is reported. The compatibility of the imidazolium unit was demonstrated with DIC or DCC coupling reactions of protected amino acids and with classical cleavage of BOC or Fmoc protecting groups. In addition, this is the first report of a traceless ionic liquid support based on a silicon linker with a high loading (3 mmol/g) of aryl bromide reactive groups used in a palladium-catalyzed carbon-carbon coupling reaction.

Cite this article as:

Bonnette Fabien, Mincheva Zoia and Lavastre Olivier, Functionalized Ionic Liquids as New Supports for Peptide Coupling and Traceless Catalyzed Carbon-Carbon Coupling Reactions, Combinatorial Chemistry & High Throughput Screening 2006; 9 (3) . https://dx.doi.org/10.2174/138620706776055485