摘要
背景:丝素蛋白(SF)是一种从家蚕(Bombyx mori)获得的天然原料,已被广泛用作具有优异机械性能的生物材料。据报道,SF是各种药物输送系统以及药物输送载体的有利生物聚合物之一。 目的:本综述总结了丝素蛋白在各种给药系统中的综合应用,并通过对丝素蛋白作为聚合物进行确定性评估,提出了目前的机会和要求。 结果:SF已被报道为用于各种给药系统以及给药载体的有益生物聚合物之一。 SF是无法估量的,因为它具有无毒和无抗原特性,除了在较低温度下储存时形成坚固性。与其他聚合物生物材料不同,SF在水性体系中以规定的温度,压力和pH值再生,这是其在配方中的主要优势之一。 SF纳米颗粒也用于递送蛋白质和肽。最近,SF已被用于递送抗癌剂如紫杉醇,多柔比星,氟尿苷和甲氨蝶呤,并且包括天然产物姜黄素,与其常规形式相比已显示出引起显着的生物活性。有趣的是,SF已被证明是一种用于植入物和注射药物递送应用的有前途的生物材料。 结论:在本综述中,我们总结了SF的物理和化学性质,生物相容性和非免疫原性特征及其在各种给药系统中的应用。
关键词: 生物材料,丝素蛋白,纳米粒,抗癌,药物传递,生物聚合物。
图形摘要
Current Drug Targets
Title:Silk Fibroin Based Drug Delivery Applications: Promises and Challenges
Volume: 19 Issue: 10
关键词: 生物材料,丝素蛋白,纳米粒,抗癌,药物传递,生物聚合物。
摘要: Background: Silk Fibroin (SF), a natural source material obtained from Bombyx mori, has been widely enlisted as biomaterial having outstanding mechanical properties. SF has been reported as one of the propitious bio-polymers for various drug delivery systems, as well as drug delivery vehicle.
Objective: This review is a summary of comprehensive applications of silk fibroin in various drug delivery systems, and also to present the current opportunities and requirements by furnishing a definitive assessment on silk fibroin as a polymer.
Results: SF has been reported as one of the propitious bio-polymers for various drug delivery systems, as well as drug delivery vehicle. SF is inestimable owing to its non-toxic and non-antigenic character, except for the firmness formation whilst being stored at lower temperature. Unlike other polymeric biomaterials, SF is regenerated in aqueous systems in defined temperature, pressure and pH, which is one of its major advantages in formulation. SF nanoparticles are also used to deliver proteins and peptides. Recently, SF has been used to deliver anti-cancer agents like paclitaxel, doxorubicin, floxuridine, and methotrexate, and including the natural product curcumin, has shown to elicit significant biological activity when compared to their conventional form. Interestingly, SF has shown to be a promising biomaterial for implantables and injectable drug delivery applications.
Conclusion: In the present review, we have summarized the physical and chemical properties, biocompatibility and non-immunogenic characters of SF and its applications in various drug delivery systems.
Export Options
About this article
Cite this article as:
Silk Fibroin Based Drug Delivery Applications: Promises and Challenges, Current Drug Targets 2018; 19 (10) . https://dx.doi.org/10.2174/1389450119666171227205525
DOI https://dx.doi.org/10.2174/1389450119666171227205525 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
Related Journals
Related Books
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Sol-gel Encapsulation of Biomolecules and Cells for Medicinal Applications
Current Topics in Medicinal Chemistry Genetic and Epigenetic Regulation of Phosphoinositide 3-kinase Isoforms
Current Pharmaceutical Design Natural Products as Promising Drug Candidates for the Treatment of Alzheimer’s Disease: Molecular Mechanism Aspect
Current Neuropharmacology Novel Dual Inhibitors of Nuclear Factor-Kappa B (NF-κ B) and Cyclooxygenase- 2 (COX-2): Synthesis, In Vitro Anticancer Activity and Stability Studies of Lantadene–Non Steroidal Anti-inflammatory Drug (NSAID) Conjugates
Current Topics in Medicinal Chemistry The Potent Inhibitory Effect of β-D-Mannuronic Acid (M2000) as a Novel NSAID with Immunosuppressive Property on Anti-Cyclic Citrullinated Peptide Antibodies, Rheumatoid Factor and Anti-dsDNA Antibodies in Patients with Rheumatoid Arthritis
Current Drug Discovery Technologies Human Mesotrypsin Defies Natural Trypsin Inhibitors: From Passive Resistance to Active Destruction.
Protein & Peptide Letters The Transcription Factor ETS-1: Its Role in Tumour Development and Strategies for its Inhibition
Mini-Reviews in Medicinal Chemistry Can We Selectively Reduce Appetite for Energy-Dense Foods? An Overview of Pharmacological Strategies for Modification of Food Preference Behavior
Current Neuropharmacology The Synthesis, Structure and Activity Evaluation of Secnidazole Derivatives as Helicobacter pylori Urease Inhibitors
Current Bioactive Compounds The Influence of DNA Methylation on Bone Cells
Current Genomics A Systematic in-silico Analysis of Helicobacter pylori Pathogenic Islands for Identification of Novel Drug Target Candidates
Current Genomics Poly(ethylene glycol)-polypeptide Copolymer Micelles for Therapeutic Agent Delivery
Current Pharmaceutical Biotechnology The Role of Oxaliplatin-Based Versus Cisplatin-Based Regimens in Advanced Gastric Cancer: A Systematic Review and Pooled Analysis of the Chinese Literature
Current Cancer Therapy Reviews Combination Platinum-based and DNA Damage Response-targeting Cancer Therapy: Evolution and Future Directions
Current Medicinal Chemistry Lanthionine Synthetase Component C-Like Protein 2: A New Drug Target for Inflammatory Diseases and Diabetes
Current Drug Targets Nongenomic Actions of Retinoids: Role of Nur77 and RXR in the Regulation of Apoptosis and Inflammation
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Ionic Liquids for Topical Delivery in Cancer
Current Medicinal Chemistry Extracts of Bacopa monnieri (L) Pennell Down-Regulate the Expression of Leukotriene C<sub>4</sub> Synthase mRNA in HL-60 Cells and Suppress OVAInduced Inflammation in BALB/c Mice
Current Bioactive Compounds Clients and Oncogenic Roles of Molecular Chaperone gp96/grp94
Current Topics in Medicinal Chemistry TGF-β1 Signalling, Connecting Aberrant Inflammation and Colorectal Tumorigenesis
Current Pharmaceutical Design