Abstract
Catalytic asymmetric hydrosilylation based on the use of inexpensive and handleable hydridic silanes is a very useful reaction in organic chemistry which has become the subject of special interest because of the intrinsic peculiarity of economic efficiency and environmental friendliness. Recently, a lot of structurally diverse organocatalysts have been designed and applied to this chemistry. Enantiopure organocatalysts such as formamide derivatives, picolinamide derivatives, S-chiral sulfinamide derivatives and chiral frustrated Lewis pairs (FLPs) have been proved as privileged catalysts for the enantioselective hydrosilylations. This manuscript provides an overview on the most relevant advances in this field and presents an extensive summary of the catalysis performance of the above mentioned catalysts.
Keywords: Asymmetric reduction, hydrosilylations, organocatalysts, hydridic silanes, asymmetric synthesis, Lewis Bases.
Graphical Abstract
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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