Biologics in Inflammatory and Immunomediated Arthritis

Title:Biologics in Inflammatory and Immunomediated Arthritis

Volume: 18 Issue: 12

Author(s): Michele M. Luchetti*, Devis Benfaremo and Armando Gabrielli

Affiliation:

• Dipartimento Scienze Cliniche e Molecolari, Sezione di Clinica Medica, Universita Politecnica delle Marche, Ancona,Italy

Keywords: Biologic drugs, TNF inhibitors, rheumatoid arthritis, spondyloarthritis, psoriatic arthritis, efficacy, safety.

Abstract: Background: Biologic drugs, introduced in clinical practice almost twenty years ago, represent nowadays a prominent treatment option in patients with chronic inflammatory arthritis, such as Rheumatoid Arthritis, Psoriatic Arthritis and Spondyloarthritis, that include ankylosing spondylitis and non-radiographic axial spondyloarthritis.

Methods: Several compounds targeting different pathways have been marketed and approved for the treatment of inflammatory arthritis, with a significant impact on the clinical outcomes and the natural history of the diseases.

Results: There are currently seven classes of biologics that are available for the treatment of inflammatory arthritis, each inhibiting a different aspect of the immune-driven inflammatory pathway.

They include:

• Tumor Necrosis Factor (TNF) inhibitors (infliximab, adalimumab, etanercept, golimumab and certolizumab pegol);

• Interleukin-1 (IL-1) receptor antagonists (anakinra);

• Interleukin-6 (IL-6) inhibition (tocilizumab);

• Interleukin-12/23 (IL23) inhibition (ustekinumab);

• Interleukin-17 (IL-17) inhibition (secukinumab);

• B-cell inhibition (anti-CD20, rituximab);

• T-cell costimulation inhibition (anti-CTLA-4, abatacept).

Conclusion: In this review, we will focus on the role of biologic drugs in the treatment strategies for inflammatory arthritis.

Cite this article as:

Luchetti M. Michele*, Benfaremo Devis and Gabrielli Armando, Biologics in Inflammatory and Immunomediated Arthritis, Current Pharmaceutical Biotechnology 2017; 18 (12) . https://dx.doi.org/10.2174/1389201019666171226151852