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Review Article

黄酮类化合物对与阿尔茨海默氏病有关的神经元死亡的神经保护作用

卷 26, 期 27, 2019

页: [5124 - 5136] 页: 13

弟呕挨: 10.2174/0929867325666171226103237

价格: $65

摘要

在许多社会中，阿尔茨海默氏病是与年龄相关的神经退行性病变。该疾病的某些方面与由于细胞外神经斑块的形成和细胞内神经原纤维缠结的出现而引起的神经元细胞的丧失有关，它们一起产生炎症和氧化状态。淀粉样蛋白在细胞中的积累诱导凋亡级联反应的激活，这暗示了胱天蛋白酶的激活。尽管乙酰胆碱酯酶抑制剂可减轻或消除与病理学相关的问题，但其作用仍遥遥无期，但阿尔茨海默氏病可通过乙酰胆碱酯酶抑制剂治疗。缺乏有效的治疗方法导致人们寻求基于天然产物的新的治疗选择。类黄酮包含一组酚类化合物，由于它们具有丰富的生物活性，因此引起了极大的兴趣。在当前的工作中，我们回顾了类黄酮的潜在用途以及拟议的作用机制，将其作为与阿尔茨海默氏病相关的神经细胞死亡的新治疗策略。

关键词: 抗氧化剂，细胞凋亡，线粒体，神经变性，多酚，阿尔茨海默氏病。

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