A Direct Access to N-Arylation of Guanidines by Ligand-Free, Copper Catalysis at Room Temperature

Title:A Direct Access to N-Arylation of Guanidines by Ligand-Free, Copper Catalysis at Room Temperature

Volume: 15 Issue: 8

Author(s): Manijeh Nematpour*, Elham Abedi and Elahe Abedi

Affiliation:

• Young Researchers and Elites Club, Science and Research Branch, Islamic Azad University, Tehran,Iran

Keywords: N-Arylation, ullmann coupling, guanidine, copper-catalyzed, aryl halides, organic.

Abstract: The copper (I)-catalyzed cross-coupling reactions between aryl halides and guanidines to produce N-aryl guanidines have been developed. Mild reaction conditions, good yields, ligand-free, easy work-up, no column chromatography, and ease of handling at room temperature are the main aspects of the method.

Cite this article as:

Nematpour Manijeh *, Abedi Elham and Abedi Elahe , A Direct Access to N-Arylation of Guanidines by Ligand-Free, Copper Catalysis at Room Temperature, Letters in Organic Chemistry 2018; 15 (8) . https://dx.doi.org/10.2174/1570178615666171222162430