L-Proline Catalyzed Synthesis of Various N-substituted Urea and Unsymmetrical N,N’-disubstituted Urea

Ajit     G.   Nagarkar; Vikas    N.   Telvekar

doi:10.2174/1570178615666171212145348

Abstract

Here, we report a simple and efficient method for the synthesis of different unsymmetrical N,N’-disubstituted urea and N-substituted urea derivatives using L-Proline as a green catalyst. The methodology is applicable for synthesizing various derivatives of phenylurea, diphenyl urea with excellent yield at mild condition.

Keywords: N-substituted urea, urea, amines, N, N`-disubstituted urea, L-Proline, green catalyst.

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Letters in Organic Chemistry

Title:L-Proline Catalyzed Synthesis of Various N-substituted Urea and Unsymmetrical N,N’-disubstituted Urea

Volume: 15 Issue: 11

Author(s): Ajit G. Nagarkar and Vikas N. Telvekar*

Affiliation:

Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai 400 019,India

Keywords: N-substituted urea, urea, amines, N, N`-disubstituted urea, L-Proline, green catalyst.

Abstract: Here, we report a simple and efficient method for the synthesis of different unsymmetrical N,N’-disubstituted urea and N-substituted urea derivatives using L-Proline as a green catalyst. The methodology is applicable for synthesizing various derivatives of phenylurea, diphenyl urea with excellent yield at mild condition.

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Nagarkar G. Ajit and Telvekar N. Vikas *, L-Proline Catalyzed Synthesis of Various N-substituted Urea and Unsymmetrical N,N’-disubstituted Urea, Letters in Organic Chemistry 2018; 15 (11) . https://dx.doi.org/10.2174/1570178615666171212145348

DOI https://dx.doi.org/10.2174/1570178615666171212145348	Print ISSN 1570-1786
Publisher Name Bentham Science Publisher	Online ISSN 1875-6255