摘要
背景:以前的工作设计了一个基于网络的认知训练协议。该程序利用了诱导面向任务的共同激活作为默认模式网络(DMN)一部分的多个区域的机制,以引发该网络中的功能重新布线和增加的功能连接性。 目的:在这项研究中,该项目被用于诊断轻度认知障碍的患者,以测试其在临床样本中的作用。 方法:23例轻度认知障碍患者(平均年龄73.74岁,标准差5.13,女性/男性比例13/10)分配到实验条件下,接受一个月的电脑化培训,另外14名患者(平均年龄73.14岁年,标准偏差6.16,女性/男性比率7/7)分配给控制条件经历了一个强烈的社会参与制度。患者处于阿尔茨海默病(AD)的前驱阶段,经临床随访至少两年证实。 DMN是在基线和重新测试时连同其他连接控制模式,灰质图和神经心理学概况计算的。 结果:在左顶叶DMN区域发现了一个逐条点的交互作用,表明该程序触发的连接性增加。没有发现减少以及其他网络或形态没有变化。尽管条件间认知改变没有达到统计学显着性,但它们与左顶叶区域中DMN连接性的改变正相关,支持顶叶改变有益的假设。 结论:这种认知训练计划可以上调AD中病理性下调的连接模式。我们认为,当认知干预被概念化为反复诱导共同激活的工具时,它们可以导致脑功能的临床相关改善,并且可以在AD的最早阶段帮助支持药理学和其他干预
关键词: 轻度认知障碍,认知刺激,功能磁共振成像,神经退行性疾病,神经可塑性,阿尔茨海默病,神经元网络重塑。
Current Alzheimer Research
Title:Up-regulation of DMN Connectivity in Mild Cognitive Impairment Via Network-based Cognitive Training
Volume: 15 Issue: 6
关键词: 轻度认知障碍,认知刺激,功能磁共振成像,神经退行性疾病,神经可塑性,阿尔茨海默病,神经元网络重塑。
摘要: Background: Previous work designed a network-based protocol of cognitive training. This programme exploits a mechanism of induced task-oriented co-activation of multiple regions that are part of the default mode network (DMN), to induce functional rewiring and increased functional connectivity within this network.
Objective: In this study, the programme was administered to patients with a diagnosis of mild cognitive impairment to test its effects in a clinical sample.
Method: Twenty-three patients with mild cognitive impairment (mean age: 73.74 years, standard deviation 5.13, female/male ratio 13/10) allocated to the experimental condition, underwent one month of computerised training, while fourteen patients (mean age: 73.14 years, standard deviation 6.16, female/ male ratio 7/7) assigned to the control condition underwent a regime of intense social engagement. Patients were in the prodromal stage of Alzheimer's disease (AD) as confirmed by clinical follow ups for at least two years. The DMN was computed at baseline and retest, together with other, control patterns of connectivity, grey matter maps and neuropsychological profiles.
Results: A condition-by-timepoint interaction indicating increased connectivity triggered by the programme was found in left parietal DMN regions. No decreases as well as no changes in the other networks or morphology were found. Although between-condition cognitive changes did not reach statistical significance, they correlated positively with changes in DMN connectivity in the left parietal region, supporting the hypothesis that parietal changes were beneficial.
Conclusion: This programme of cognitive training up-regulates a pattern of connectivity which is pathologically down-regulated in AD. We argue that, when cognitive interventions are conceptualised as tools to induce co-activation repeatedly, they can lead to clinically relevant improvements in brain functioning, and can be of aid in support of pharmacological and other interventions in the earliest stages of AD.
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Cite this article as:
Up-regulation of DMN Connectivity in Mild Cognitive Impairment Via Network-based Cognitive Training, Current Alzheimer Research 2018; 15 (6) . https://dx.doi.org/10.2174/1567205015666171212103323
DOI https://dx.doi.org/10.2174/1567205015666171212103323 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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