摘要
背景：用于治疗性单克隆抗体生产的经济有效的植物平台既灵活又可扩展。植物细胞具有蛋白质合成和翻译后修饰的机制，包括糖基化，类似于动物细胞中的那些。然而，与动物细胞相比，植物产生较少复杂和多样化的Asn附着聚糖并且含有植物特异性残基。然而，与动物细胞中产生的那些相比，植物制备的抗体（PMAb）可能是有利的，因为没有动物来源的核酸或蛋白质污染的风险。 目的：本文综述了PMAbs生产的各种平台，并详细讨论了基于农杆菌介导的遗传物质向植物细胞中传递的广泛使用的瞬时表达系统。 结果：我们检查了人源化PMAb的Asn连接聚糖的特征和方法。 PMAb在预防和治疗人类感染性疾病方面的前景已经通过PMAb对抗人类免疫缺陷病毒，轮状病毒感染，人呼吸道合胞病毒，狂犬病，炭疽和埃博拉病毒的有希望的结果得到了说明。针对不同类型癌症（包括淋巴瘤和乳腺癌）的PMAb的临床前和临床试验得到了解决。 结论：患者的PMAb生物安全性评估表明它没有副作用，尽管这并没有完全消除对某些植物聚糖在人体中潜在免疫原性的担忧。已经提出了几个处于不同发育阶段的PMAb。对PMAbs临床应用的承诺旨在治疗病毒和细菌感染以及抗癌治疗。
关键词: 植物产生的抗体，单克隆抗体，免疫疗法，治疗性抗体，抗体糖基化，PMab。
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