摘要
饮食是影响糖尿病发展和风险的重要因素。为了寻求预防和治疗策略,应考虑某些食物及其生物活性化合物预防与代谢疾病相关的发病机制的潜在作用。人类花青素的消耗量是所有黄酮类化合物中最高的。流行病学研究表明,花青素的消耗可降低患糖尿病和糖尿病并发症的风险。花青素是重要的天然生物活性色素,其负责水果,叶子,种子,茎和花的红色至蓝色,其存在于多种植物物种中,特别是在浆果和樱桃中。大量的生物活性花青素,如花青素,malvidin,飞燕草素,天竺葵素,芍药苷,矮牵牛花素及其代谢产物已经显示出多种生物活性,对葡萄糖吸收,葡萄糖摄取,胰岛素分泌和敏感性,参与葡萄糖代谢的酶有明显影响。 ,基因表达,炎症介质,糖尿病进展中的葡萄糖转运蛋白和相关并发症,例如糖尿病性视网膜病,肾病,神经病和糖尿病性血管疾病。与合成药物相比,花青素的多功能性为糖尿病管理提供了有前途的方法。在这里,我们总结了几种花青素对许多体外,体内和临床研究的影响,并揭示了可以预防或逆转糖尿病病理学的潜在机制的机制,包括促进抗氧化,抗高血脂,抗炎和抗细胞凋亡活性。
关键词: 花青素,糖尿病,葡萄糖,并发症,饮食,预防和治疗策略.
Current Medicinal Chemistry
Title:Preventive and Therapeutic Potentials of Anthocyanins in Diabetes and Associated Complications
Volume: 25 Issue: 39
关键词: 花青素,糖尿病,葡萄糖,并发症,饮食,预防和治疗策略.
摘要: Diet is an essential factor affecting the development of and risk for diabetes mellitus. In search of preventative and therapeutic strategies, the potential role of certain foods and their bioactive compounds to prevent the pathogenesis associated with metabolic diseases is to be considered. Human consumption of anthocyanins is among the highest of all flavonoids. Epidemiological studies have suggested that the consumption of anthocyanins lowers the risk of diabetes and diabetic complications. Anthocyanins are important natural bioactive pigments responsible for red to blue colour of fruits, leaves, seeds, stems and flowers, which are present in a variety of plant species particularly in berries and cherries. A large number of bioactive anthocyanins, such as cyanidin, malvidin, delphinidin, pelargonidin, peonidin, petunidin and their metabolites have shown multiple biological activities with apparent effects on glucose absorption, glucose uptake, insulin secretion and sensitivity, on the enzymes involved in glucose metabolism, gene expressions, inflammatory mediators, glucose transporters in progression of diabetes and associated complications, such as diabetic retinopathy, nephropathy, neuropathy and diabetic vascular diseases. The versatility of the anthocyanins provides a promising approach for diabetes management than synthetic drugs. Here we summarize the effect of several anthocyanins on many in vitro, in vivo and clinical studies and also reveal the mechanisms which could prevent or reverse the underlying mechanisms of diabetic pathologies including promotion of antioxidant, antihyperlipidemic, anti-inflammatory and anti-apoptotic activities.
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Cite this article as:
Preventive and Therapeutic Potentials of Anthocyanins in Diabetes and Associated Complications, Current Medicinal Chemistry 2018; 25 (39) . https://dx.doi.org/10.2174/0929867325666171206101945
DOI https://dx.doi.org/10.2174/0929867325666171206101945 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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