Amino Acid Catalyzed Synthesis of 2,3-Dihydroquinazolin-4(1H)-One Derivatives

Title:Amino Acid Catalyzed Synthesis of 2,3-Dihydroquinazolin-4(1H)-One Derivatives

Volume: 15 Issue: 4

Author(s): K. Mohammed Mustaque, A. Subramani, T.K. Shabeer, H. Thajudeen and V.S. Jamal Ahamed*

Affiliation:

• PG and Research Dept. of Chemistry, The New College, Chennai-600014, Tamilnadu,India

Keywords: Amino acid, catalyst, 2, 3-Dihydroquinazolin-4(1H)-ones, 2-aminobenzamide, ketones, water.

Abstract: A simple, convenient and facile approach for the synthesis of a series of 2,3- dihydroquinazolin-4(1H)-ones in an environmentally benign method has been developed. This method involves a direct cyclocondensation of 2-aminobenzamide with aromatic aldehydes and ketones using aspartic acid as a catalyst in water.

Cite this article as:

Mustaque Mohammed K. , Subramani A. , Shabeer T.K. , Thajudeen H. and Ahamed Jamal V.S. *, Amino Acid Catalyzed Synthesis of 2,3-Dihydroquinazolin-4(1H)-One Derivatives, Letters in Organic Chemistry 2018; 15 (4) . https://dx.doi.org/10.2174/1570178614666171130154814