摘要
含硒小分子由于其抗肿瘤作用,心血管保护作用,抗菌或抗病毒作用,免疫调节和神经保护等多种生物学活性而受到化学和医学研究人员的广泛关注,其中最有希望的领域是抗肿瘤药物。在过去的几十年中,已报道了不同种类的有机硒化合物如硒化物,硒(异)氰酸酯,取代的硒脲,亚硒酸酯和含硒杂环作为抗癌剂的候选物。目前关于含硒抗癌化合物的综述主要关注其生物活性的研究,而关于其合成方法的研究却很少受到关注。在此,我们总结了最近开发的用于合成具有强抗肿瘤特性的有机硒化合物的方法,这将有助于进一步设计和合成具有不同结构特征的新的具有生物活性的含硒分子。
关键词: 抗肿瘤,硒,合成途径,抗肿瘤药物,癌症,分子。
Current Medicinal Chemistry
Title:Recent Advances for the Synthesis of Selenium-containing Small Molecules as Potent Antitumor Agents
Volume: 25 Issue: 17
关键词: 抗肿瘤,硒,合成途径,抗肿瘤药物,癌症,分子。
摘要: Selenium-containing small molecules have attracted considerable attention of chemical and medicinal researchers owing to their various biological activities, such as antitumor effects, cardiovascular protection, antibacterial or antiviral effects, immunoregulation and nerve protection, among which the most promising area is antineoplasm. In the past several decades, different kinds of organoselenium compounds, such as selenides, seleno(iso)cyanates, substituted selenoureas, selenious esters and Se-containing heterocycles have been reported as candidates of anti-cancer agents. Current reviews of Se-containing anticancer compounds mainly concerned about the investigation of their bioactivities, whereas, few attention has been addressed on their synthetic approaches. Herein, we summarized methodologies recently developed to synthesize organoselenium compounds with potent antineoplastic properties, which would be helpful for further design and synthesis of new bioactive Se-containing molecules with diverse structural features.
Export Options
About this article
Cite this article as:
Recent Advances for the Synthesis of Selenium-containing Small Molecules as Potent Antitumor Agents, Current Medicinal Chemistry 2018; 25 (17) . https://dx.doi.org/10.2174/0929867325666171129220544
DOI https://dx.doi.org/10.2174/0929867325666171129220544 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Some Recent Synthetic Development on Compounds with Potent Activities on Hormone-sensitive Breast Cancers
Current Organic Chemistry Autophagy Regulators as Potential Cancer Therapeutic agents: A Review
Current Topics in Medicinal Chemistry Homologation: A Versatile Molecular Modification Strategy to Drug Discovery
Current Topics in Medicinal Chemistry Emerging Therapy for Diabetic Neuropathy: Cell Therapy Targeting Vessels and Nerves
Endocrine, Metabolic & Immune Disorders - Drug Targets Neuroprotective Effects of <i>Nardostachys jatamansi</i> Against BSO Induced Anxiety via its Antioxidant Machinery and by Elevating Catecholamines and GABA levels in Mice
Current Traditional Medicine New Treatments for Emerging Cystic Fibrosis Pathogens other than Pseudomonas
Current Pharmaceutical Design Directing Hypoxic Tumor Microenvironment and HIF to Illuminate Cancer Immunotherapy's Existing Prospects and Challenges in Drug Targets
Current Drug Targets Recent Highlights on Molecular Hybrids Potentially Useful in Central Nervous System Disorders
Mini-Reviews in Medicinal Chemistry Eicosanoids in Prevention and Management of Diseases
Current Molecular Medicine Adenosine and ATP Receptors in the Brain
Current Topics in Medicinal Chemistry Metabolism of Flavonoids in Human: A Comprehensive Review
Current Drug Metabolism Selectively Replicating Adenoviruses for Oncolytic Therapy
Current Cancer Drug Targets Maternal Sepsis 2010: Early Recognition and Aggressive Treatment with Early Goal Directed Therapy can Improve Maternal Outcomes
Current Women`s Health Reviews Cholinergic Receptors as Target for Cancer Therapy in a Systems Medicine Perspective
Current Molecular Medicine The Initiation Mechanisms of Gene Expression in Ascitic Hepatoma Cells Under the Action of Dehydroepiandrosterone in a Complex with Apolipoprotein A-I
Current Chemical Biology Predictors and Clinical Implications of HPV Reservoire Districts for Genital Tract Disease
Current Pharmaceutical Design Opioid Growth Factor and its Derivatives as Potential Non-toxic Multifunctional Anticancer and Analgesic Compounds
Current Medicinal Chemistry Role of Flavonoids in Future Anticancer Therapy by Eliminating the Cancer Stem Cells
Current Stem Cell Research & Therapy Targeting Key Transporters in Tumor Glycolysis as a Novel Anticancer Strategy
Current Topics in Medicinal Chemistry Purification and Characterization of a Lectin of the Swartzieae Legume Taxa
Protein & Peptide Letters