摘要
含硒小分子由于其抗肿瘤作用,心血管保护作用,抗菌或抗病毒作用,免疫调节和神经保护等多种生物学活性而受到化学和医学研究人员的广泛关注,其中最有希望的领域是抗肿瘤药物。在过去的几十年中,已报道了不同种类的有机硒化合物如硒化物,硒(异)氰酸酯,取代的硒脲,亚硒酸酯和含硒杂环作为抗癌剂的候选物。目前关于含硒抗癌化合物的综述主要关注其生物活性的研究,而关于其合成方法的研究却很少受到关注。在此,我们总结了最近开发的用于合成具有强抗肿瘤特性的有机硒化合物的方法,这将有助于进一步设计和合成具有不同结构特征的新的具有生物活性的含硒分子。
关键词: 抗肿瘤,硒,合成途径,抗肿瘤药物,癌症,分子。
Current Medicinal Chemistry
Title:Recent Advances for the Synthesis of Selenium-containing Small Molecules as Potent Antitumor Agents
Volume: 25 Issue: 17
关键词: 抗肿瘤,硒,合成途径,抗肿瘤药物,癌症,分子。
摘要: Selenium-containing small molecules have attracted considerable attention of chemical and medicinal researchers owing to their various biological activities, such as antitumor effects, cardiovascular protection, antibacterial or antiviral effects, immunoregulation and nerve protection, among which the most promising area is antineoplasm. In the past several decades, different kinds of organoselenium compounds, such as selenides, seleno(iso)cyanates, substituted selenoureas, selenious esters and Se-containing heterocycles have been reported as candidates of anti-cancer agents. Current reviews of Se-containing anticancer compounds mainly concerned about the investigation of their bioactivities, whereas, few attention has been addressed on their synthetic approaches. Herein, we summarized methodologies recently developed to synthesize organoselenium compounds with potent antineoplastic properties, which would be helpful for further design and synthesis of new bioactive Se-containing molecules with diverse structural features.
Export Options
About this article
Cite this article as:
Recent Advances for the Synthesis of Selenium-containing Small Molecules as Potent Antitumor Agents, Current Medicinal Chemistry 2018; 25 (17) . https://dx.doi.org/10.2174/0929867325666171129220544
DOI https://dx.doi.org/10.2174/0929867325666171129220544 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Outfielders Playing in the Infield: Functions of Aging-Associated "Nuclear" Proteins in the Mitochondria
Current Molecular Medicine Anti-Cancer Compounds from Terrestrial and Marine Resources -In silico and Experimental Studies
Current Computer-Aided Drug Design The Functions of Polo-Like Kinases and their Relevance to Human Disease
Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents Asymmetric Dimethylarginine: Clinical Significance and Novel Therapeutic Approaches
Current Medicinal Chemistry Focal Adhesion Kinase: From In Vitro Studies to Functional Analyses In Vivo
Current Protein & Peptide Science Angiogenesis as a Therapeutic Target in Arthritis: Lessons from Oncology
Current Pharmaceutical Design Herpes Simplex Virus Vectors for the Nervous System
Current Gene Therapy Tissue-Based Approaches to Study Pharmacodynamic Endpoints in Early Phase Oncology Clinical Trials
Current Drug Targets Role of Polysaccharides Mimetic Components in Targeted Cancer Treatment
Current Drug Targets Phytocompounds from the Medicinal and Dietary Plants: Multi-target Agents for Cervical Cancer Prevention and Therapy
Current Medicinal Chemistry Anticancer Drug Discovery Targeting DNA Hypermethylation
Current Medicinal Chemistry Tumor Specific Novel Taxoid-Monoclonal Antibody Conjugates
Current Medicinal Chemistry Cell Penetrating Peptide Delivery of Splice Directing Oligonucleotides as a Treatment for Duchenne Muscular Dystrophy
Current Pharmaceutical Design Castration Resistant Prostate Cancer: From Emerging Molecular Pathways to Targeted Therapeutic Approaches
Clinical Cancer Drugs Therapeutic Potential of Group III Metabotropic Glutamate Receptors
Current Medicinal Chemistry The Eker Rat: Establishing a Genetic Paradigm Linking Renal Cell Carcinoma and Uterine Leiomyoma
Current Molecular Medicine Elucidation of Pathophysiology and Treatment of Neuropathic Pain
Central Nervous System Agents in Medicinal Chemistry Oral HPV Infection: Current Strategies for Prevention and Therapy
Current Pharmaceutical Design Tumor Angiogenesis: A Potential Target In Cancer Control by Phytochemicals
Current Cancer Drug Targets The Impacts of Non-coding RNAs and N<sup>6</sup>-Methyladenosine on Cancer: Past, Present and Future
Current Cancer Drug Targets