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General Review Article

使用抗生素负载生物材料治疗骨质假体感染：基本原理和限量

卷 26, 期 17, 2019

页: [3150 - 3174] 页: 25

弟呕挨: 10.2174/0929867325666171129220031

价格: $65

摘要

背景：假体周围感染对于骨科社区来说仍然是一个具有挑战性的问题。 在美国，每年大约有一百万例关节成形术，感染率在1％至2％之间：修订对医疗保健成本和适当的资源管理具有重要意义。 在消除任何微生物和加强全身治疗的有效性方面，最终确定使用局部应用的抗生素作为预防措施或作为初级或翻修手术中治疗方法的组成部分。 目的：本临床和临床前体内研究的综述试图确定临床骨科实践所用材料的优点和局限性，并讨论开发的生物材料，创新治疗方法或在感染环境中释放抗生素的策略。 方法：两个独立观察员在两个数据库（www.pubmed.com和www.scopus.com）中进行系统检索，以确定过去10年的临床前和临床报告。 结果：71篇论文被认可合格：15篇文章为临床研究，56篇为体内研究。 结论：聚甲基丙烯酸甲酯是用于治疗全关节置换术后感染的先驱生物材料。 尽管广泛使用，但仍存在争议的几个问题：结合材料和抗生素的方法，抗生素的选择，释放动力学和抗生素功效。 在过去几年中，人们的兴趣是针对不同抗生素的选择，这些抗生素与超过一种类别和生物材料相关联，特别关注作为植入物表面涂层，水凝胶，陶瓷，微载体，微球或纳米颗粒的递送系统。

关键词: 假体周围感染，生物材料，抗生素，髋关节，膝关节，假体周围关节，假体。

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