摘要
背景:在过去的几十年里,合成聚合物基电纺纳米纤维/微纤维在组织工程、药物输送等重要生物医学应用中已成为有潜力的材料。d诊断。 这主要归因于电纺(ES)工艺的通用性和可重复性以及所产生的纳米结构的高表面体积比。 挪用用专用生物分子(如细胞粘附肽、治疗分子、生物探针)进行TE功能化是这类材料在相关appl中的重要性能要求。ication. 方法:介绍几种制备生物功能化合成聚合物纤维的化学方法,主要有两种方法:ES工艺后引入生物分子(Pos)。在ES之前。然后,我们重点研究了这些材料在组织工程、药物传递和诊断领域的最新影响。 结果:本文介绍了为设计生物功能化纤维而开发的多种固定化策略(共价或非共价),以及它们对生物功能化纤维性能的影响。还重点介绍了用于生物功能化的先进共轭工具(“可点击”化学物质、PEG连接剂)的投入。从文献来看,我目前正致力于多功能特性和纤维与其他材料(水凝胶、无机粒子、微流控装置)的结合,以改善和调节香水的性能。romances浪漫史( romance的名词复数 ) 结论:由于ES工艺的灵活性和稳健性,以及共轭和聚合物/材料工程的进展,现在可以实现对生物功能化的高度控制。尽可能符合目标应用程序的要求。到目前为止,这些表演对这类材料的未来是个好兆头。
关键词: 合成聚合物,静电纺丝,生物功能化,共轭化学,组织工程,药物传递,诊断。
Current Medicinal Chemistry
Title:Synthetic Polymer-based Electrospun Fibers: Biofunctionalization Strategies and Recent Advances in Tissue Engineering, Drug Delivery and Diagnostics
Volume: 25 Issue: 20
关键词: 合成聚合物,静电纺丝,生物功能化,共轭化学,组织工程,药物传递,诊断。
摘要: Background: Over the last decades, synthetic polymer-based electrospun nano/microfibers have emerged as potent materials in crucial biomedical applications such as tissue engineering, drug delivery and diagnostics. This is mainly attributed to versatility and reproducibility of the electrospinning (ES) process, as well as the high surface- to-volume ratio of the generated nanostructures. Appropriate functionalization with dedicated biomolecules (i.e. cell adhesive peptides, therapeutic molecules, bio-probes) is a critical requirement for the performances of such materials in their related application.
Methods: We report on the different chemical methodologies for preparing biofunctionalized synthetic polymer fibers, on the basis of two main approaches: biomolecule introduction after ES process (post-ES) and before ES (pre-ES). We then focused on the latest implications of such materials in areas of tissue engineering, drug delivery and diagnostics.
Results: This review describes the numerous immobilization strategies (either covalent or non-covalent) developed for designing biofunctionalized fibers, as well as their impact on their properties in dedicated application. The inputs of advanced conjugation tools (“clickable” chemistries, PEG linkers) for biofunctionalization are also highlighted. In the light of the literature, it appears that increasing research efforts are now devoted to multifunctional character and fiber combination with other materials (hydrogels, inorganic particles, microfluidic devices) for improved and tunable performances.
Conclusion: Owing to flexibility and robustness of ES process as well as advances in conjugation and polymer/material engineering, high degree of control over biofunctionalization can now be achieved, to fit as best as possible the requirements of the targeted application. The performances reached up to now augur well for the future of such class of materials.
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Cite this article as:
Synthetic Polymer-based Electrospun Fibers: Biofunctionalization Strategies and Recent Advances in Tissue Engineering, Drug Delivery and Diagnostics, Current Medicinal Chemistry 2018; 25 (20) . https://dx.doi.org/10.2174/0929867325666171129133120
DOI https://dx.doi.org/10.2174/0929867325666171129133120 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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