Copper Catalyzed Ligand Free Microwave Mediated Synthesis of α-ketoamides from Aromatic Ketones

Title:Copper Catalyzed Ligand Free Microwave Mediated Synthesis of α-ketoamides from Aromatic Ketones

Volume: 5 Issue: 1

Author(s): Kshipra S. Karnik, Aniket P. Sarkate, Shritesh D. Jagtap and Pravin S. Wakte*

Affiliation:

• Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad-431004, (MS),India

Keywords: Aryl methyl ketones, copper chloride, microwave, secondary amines, α-ketoamides, synthetic protocol.

Abstract: Background: An efficient, microwave assisted, copper catalyzed synthetic protocol for α- ketoamides has been developed by using secondary amines.

Methods: In the synthetic method, the targeted α-ketoamides were synthesized with the help of microwave by reacting secondary amines and aryl methyl ketones in the presence of copper chloride and hydrogen peroxide.

Results: α-ketoamides were prepared in good yields (within 10mins) with the help of a microwave irradiation. The reported protocol is ligand free and the yields of the derivatives were modest to excellent.

Conclusion: Microwave assisted technique will be a useful alternative method for the preparation of α-ketoamides.

Cite this article as:

Karnik S. Kshipra , Sarkate P. Aniket , Jagtap D. Shritesh and Wakte S. Pravin *, Copper Catalyzed Ligand Free Microwave Mediated Synthesis of α-ketoamides from Aromatic Ketones, Current Microwave Chemistry 2018; 5 (1) . https://dx.doi.org/10.2174/2213335604666171128150721