酚酸发挥抗胆碱酯酶和改善认知功能

Title:Phenolic Acids Exert Anticholinesterase and Cognition-Improving Effects

Volume: 15 Issue: 6

关键词: 阿尔茨海默病，淀粉样β肽，肉桂酸，苯甲酸，乙酰胆碱酯酶，丁酰胆碱酯酶，认知。

摘要: Numerous authors have provided evidence regarding the beneficial effects of phenolic acids and their derivatives against Alzheimer's disease (AD). In this review, the role of phenolic acids as inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) is discussed, including the structure-activity relationship. In addition, the inhibitory effect of phenolic acids on the formation of amyloid β-peptide (Aβ) fibrils is presented. We also cover the in vitro, ex vivo, and in vivo studies concerning the prevention and treatment of the cognitive enhancement.

Cite this article as:

Phenolic Acids Exert Anticholinesterase and Cognition-Improving Effects, Current Alzheimer Research 2018; 15 (6) . https://dx.doi.org/10.2174/1567205014666171128102557