Current Challenges and Future of Lipid Nanoparticles Formulations for Topical Drug Application to Oral Mucosa, Skin, and Eye

Title:Current Challenges and Future of Lipid Nanoparticles Formulations for Topical Drug Application to Oral Mucosa, Skin, and Eye

Volume: 23 Issue: 43

Author(s): Viviane A. Guilherme, Ligia N.M. Ribeiro, Giovana Radomille Tofoli, Michelle Franz-Montan, Eneida de Paula and Marcelo Bispo de Jesus*

Affiliation:

• Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas - UNICAMP, Campinas, Sao Paulo,Brazil

Keywords: Solid lipid nanoparticles, nanostructured lipid carriers, drug delivery, topical application, first pass metabolism, gastrointestinal tract.

Abstract: Background: Topical drug administration offers an attractive route with minimal invasiveness. It also avoids limitations of intravenous administration such as the first pass metabolism and presystemic elimination within the gastrointestinal tract. Furthermore, topical drug administration is safe, have few side effects, is easy to apply, and offers a fast onset of action. However, the development of effective topical formulations still represents a challenge for the desired effect to be reached, locally or systemically. Solid lipid nanoparticles and nanostructured lipid carriers are particular candidates to overcome the problem of topical drug administration. The nanometric particle size of lipid nanoparticles favors the physical adhesion to the skin or mucosal, what can also be attained with the formation of hybrid (nanoparticles/polymer) systems.

Methods: In this review, we discuss the major challenges for lipid nanoparticles formulations for topical application to oral mucosa, skin, and eye, highlighting the strategies to improve the performance of lipid nanoparticles for topical applications. Next, we critically analyzed the in vitro and in vivo approaches used to evaluate lipid nanoparticles performance and toxicity.

Conclusion: We addressed some major drawbacks related to lipid nanoparticle topical formulations and concluded the key points that have to be overcome to help them to reach the market in topical formulations to oral mucosa, skin, and eye.

Cite this article as:

Guilherme A. Viviane , Ribeiro N.M. Ligia, Tofoli Radomille Giovana , Franz-Montan Michelle , de Paula Eneida and de Jesus Bispo Marcelo*, Current Challenges and Future of Lipid Nanoparticles Formulations for Topical Drug Application to Oral Mucosa, Skin, and Eye, Current Pharmaceutical Design 2017; 23 (43) . https://dx.doi.org/10.2174/1381612823666171122103849