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Combinatorial Chemistry & High Throughput Screening

Editor-in-Chief

ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

Numerical Characterization and Similarity Analysis of DNA Sequences Based on 2-D Graphical Representation of the Characteristic Sequences

Author(s): Chun Li and Jun Wang

Volume 6, Issue 8, 2003

Page: [795 - 799] Pages: 5

DOI: 10.2174/138620703771826900

Price: $65

Abstract

Based on the classifications of the four nucleic acid bases, He and Wang reduced a DNA sequence to three binary sequences, which are called the characteristic sequences (J. Chem. Inf. Comput. Sci. 42 (2002) 1080). In this paper, we associate each characteristic sequence with a bL / bL matrix by giving a 2-D ‘two horizontal lines’ graphical representation, and thus obtain a 3-component vector with entries being the sums of the maximal and minimal eigenvalues of the bL / bL matrices. The introduced vector results in more simple characterizations and comparisons among the coding sequences of exon 1 of beta-globin gene of eleven different species.

Keywords: dna, characteristic sequence, graphical representation, matrix, eigenvalue


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