摘要
背景:胆汁酸是胆汁的主要成分之一。最近,它们也被认为是重要的信号分子,不仅通过调节它们自身的合成,而且还发挥作用i。多种代谢性疾病。 目的:研究脱氧胆酸钠(NaDOC)、熊去氧胆酸(UDCA)和利胆酸(LCA)及其组合对肠道Ca2+吸收的影响。制作CL倾听这些BAs在这个生理过程中的作用,概述目前关于肠道Ca2+发生的机制的信息。 方法:检索PubMed数据库至2017年,使用胆汁酸、NaDOC、UDCA、LCA、氧化还原状态、细胞凋亡、自噬和肠钙吸收等关键词。 结果:氧化还原状态的调节、细胞凋亡和自噬是BAS对肠内Ca2+吸收的作用机制。尽管这些机制还没有完全实现最后,我们提供了有关BAS对肠道钙吸收影响的最新知识。 结论:BAS影响肠道对Ca2+的吸收反应,但与BA的类型和剂量有关。当有一个单一的管理,NaDOC有一个抑制的ef。FECT,UDCA是刺激器,而LCA没有任何影响。然而,BAS的组合改变了响应。无论是UDCA还是LCA都能保护肠道免受氧化损伤的影响。D通过阻断氧化/亚硝基应激、凋亡和自噬作用而被NaDOC所阻断。
关键词: 胆汁酸、肠钙吸收、NaDOC、UDCA、LCA、氧化应激、自噬、亚硝化应激、凋亡。
Current Medicinal Chemistry
Title:Molecular Mechanisms Triggered by Bile Acids on Intestinal Ca2+ Absorption
Volume: 25 Issue: 18
关键词: 胆汁酸、肠钙吸收、NaDOC、UDCA、LCA、氧化应激、自噬、亚硝化应激、凋亡。
摘要: Background: Bile acids (BAs) are among the main components of bile. Lately, they are also considered important signaling molecules, not only by regulating their own synthesis, but also having a role in several metabolic diseases.
Objective: In this review we focus on the effect of sodium deoxycholate (NaDOC), ursodeoxycholic (UDCA) and litocholic (LCA) acids and their combination upon the intestinal Ca2+ absorption. To make clear the actions of those BAs on this physiological process, an overview of current information about the mechanisms by which the intestinal Ca2+ occurs is described.
Methods: The PubMed database was searched until 2017, using the keywords bile acids, NaDOC, UDCA and LCA and redox state, apoptosis, autophagy and intestinal Ca2+ absorption.
Results: The modulation of redox state, apoptosis and autophagy are mechanisms that are involved in the action of BAs on intestinal Ca2+ absorption. Although the mechanisms are still not completely understood, we provide the latest knowledge regarding the effect of BAs on intestinal Ca2+ absorption.
Conclusion: The response of the intestine to absorb Ca2+ is affected by BAs, but it is different according to the type and dose of BA. When there is a single administration, NaDOC has an inhibitory effect, UDCA is an stimulator whereas LCA does not have any influence. However, the combination of BAs modifies the response. Either UDCA or LCA protects the intestine against the oxidative injury caused by NaDOC by blocking the oxidative/nitrosative stress, apoptosis and autophagy.
Export Options
About this article
Cite this article as:
Molecular Mechanisms Triggered by Bile Acids on Intestinal Ca2+ Absorption, Current Medicinal Chemistry 2018; 25 (18) . https://dx.doi.org/10.2174/0929867324666171116125131
DOI https://dx.doi.org/10.2174/0929867324666171116125131 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Vitiligo: Pathogenetic Hypotheses and Targets for Current Therapies
Current Drug Metabolism Pregnancy-Associated Plasma Protein-A and its Role in Cardiovascular Disease. Biology, Experimental/Clinical Evidences and Potential Therapeutic Approaches
Current Vascular Pharmacology Acute Effects of Neutrophil-Derived Oxidative Stress on Pulmonary Microvasculature
Current Respiratory Medicine Reviews Current State of the Art of New Tubulin Inhibitors in the Clinic
Current Clinical Pharmacology Artificial Hibernation by Phenothiazines: A Potential Neuroprotective Therapy Against Cerebral Inflammation in Stroke
Current Neurovascular Research Thyroid Hormone-Induced Angiogenesis
Current Cardiology Reviews Rediscovery of Caffeine: An Excellent Drug for Improving Patient Outcomes while Fighting WARS
Current Medicinal Chemistry HCV Inhibitors: Role of Compounds from Botanical Sources
Current Topics in Medicinal Chemistry Monitoring Calcific Aortic Valve Disease: The Role of Biomarkers
Current Medicinal Chemistry Nitric Oxide and Cardiovascular Dysfunction in Sepsis
Endocrine, Metabolic & Immune Disorders - Drug Targets Balaglitazone: A Second Generation Peroxisome Proliferator-Activated Receptor (PPAR) Gamma (γ) Agonist
Mini-Reviews in Medicinal Chemistry Genetic and Environmental Factors in Complex Neurodevelopmental Disorders
Current Genomics An Unbiased Predictive Model to Detect DNA Methylation Propensity of CpG Islands in the Human Genome
Current Bioinformatics Mechanisms of Drug Resistance to Vascular Endothelial Growth Factor (VEGF) Inhibitors
Anti-Cancer Agents in Medicinal Chemistry Structural, Functional and Therapeutic Aspects of Snake Venom Metalloproteinases
Mini-Reviews in Organic Chemistry Pharmacokinetics and Systemic Activity of a New Patent of an Inhaled Corticosteroid/Long-Acting β2-Agonist Combination for Use in Asthma Therapy: Fluticasone Furoate/Vilanterol Trifenatate
Recent Patents on Inflammation & Allergy Drug Discovery Recent Developments in the Search for Biomarkers for the Diagnosis and Monitoring of Diabetes
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery (Discontinued) Is there Any Correlation Between Binding and Functional Effects at the Translocator Protein (TSPO) (18 kDa)?
Current Molecular Medicine Hepatic Angiogenesis and Fibrogenesis in the Progression of Chronic Liver Diseases
Current Angiogenesis (Discontinued) Recent Progress in the Design and Discovery of RXR Modulators Targeting Alternate Binding Sites of the Receptor
Current Topics in Medicinal Chemistry