自噬作为乳腺癌治疗的潜在靶点

Title:Autophagy as a Potential Therapeutic Target in Breast Cancer Treatment

Volume: 18 Issue: 7

关键词: 自噬，乳腺癌，靶向治疗，受体，组蛋白去乙酰化酶，溶酶体，微管。

摘要: One of the crucial reasons of breast cancer therapy failure is an impairment of mechanisms responsible for metabolism and cellular homeostasis, which makes it difficult to foresee the response to the treatment. Targeted therapy in breast cancer is dictated by the expression of specific molecules such as growth factor or hormone receptors. Many types of breast cancer exhibit different abnormalities in the apoptotic pathway, which confer the resistance to many forms of chemotherapy. Because of the fundamental importance of autophagy in the development and progression of cancer and its ability to affect treatment response, there has been an immense research on molecular regulation and signal transduction mechanisms that control this process. Here, we summarize the present knowledge concerning different breast cancer treatment strategies using drugs approved for the treatment of different breast cancer molecular subtypes with targeting pathways and factors associated with autophagy modulation/ regulation.

Cite this article as:

Autophagy as a Potential Therapeutic Target in Breast Cancer Treatment, Current Cancer Drug Targets 2018; 18 (7) . https://dx.doi.org/10.2174/1568009617666171114143330