摘要
背景:异黄酮是属于异黄酮类化合物的天然化合物,具有基于3-苯基色烯-4-酮主链的化学结构。作为一种特殊的元素,异黄酮也被称为植物雌激素,因为它与17-β雌二醇(主要是雌性激素)具有雌激素激动剂和雌激素拮抗剂性质的结构相似性。这类次生植物代谢物已在文献中广泛报道用于广泛的治疗活性,包括抗氧化剂,化学预防剂,抗炎剂,抗过敏剂,抗细菌剂和心脏预防作用。 目标:总结关于在膳食来源中发现的主要异黄酮作为天然抗炎剂的最新信息。 结果:该综述更新了关于染料木黄酮,大豆黄素,黄豆黄素,鹰嘴豆芽素A,芒柄花素和雌马酚作为抗炎植物化合物的最新研究。作为一个特别的因素,还讨论了这些异黄酮在炎症和血管生成之间的联系的含义。 结论:综述认为,饮食中的主要异黄酮通过激活各种生化和分子机制显示体外和/或体内抗炎潜能。将所描述的发现转化为实际方面强化了异黄酮染料木黄酮,大豆黄素,黄豆黄素,鹰嘴豆芽素A,芒柄花素和雌马酚可用于各种基于炎症的疾病作为经典药物的替代来源以及富含异黄酮的食物的完善可代表先决条件使用,以防止基于炎症的疾病的演变
关键词: 炎症,染料木黄酮,大豆黄素,黄豆黄素,鹰嘴豆芽素A,芒柄花素,牛尿酚,血管生成
图形摘要
Current Drug Targets
Title:Main Isoflavones Found in Dietary Sources as Natural Anti-inflammatory Agents
Volume: 19 Issue: 7
关键词: 炎症,染料木黄酮,大豆黄素,黄豆黄素,鹰嘴豆芽素A,芒柄花素,牛尿酚,血管生成
摘要: Background: Isoflavones are natural compounds belonging to the class of isoflavonoids, molecules with a chemical structure based on the 3-phenyl chromen-4-one backbone. As a particular element, the isoflavones are also called phytoestrogens, due to the structural similarity with 17-β estradiol, the primary female sex hormone, presenting both estrogen-agonist and estrogen-antagonist properties. This class of secondary plant metabolites has been extensively reported in the literature for a wide range of therapeutic activities including antioxidant, chemopreventive, anti-inflammatory, antiallergic, antibacterial, and cardio preventive effects.
Objective: To sum up the latest information regarding the main isoflavones found in dietary sources as natural anti-inflammatory agents.
Results: The review updates with the recent research about genistein, daidzein, glycitein, biochanin A, formononetin and equol as anti-inflammatory phytocompounds. As a particular element, the implications of these isoflavones in the link between inflammation and angiogenesis are also discussed.
Conclusion: The review concludes that the main isoflavones in dietary sources display in vitro and/or in vivo anti inflammatory potential by activating various biochemical and molecular mechanisms. The depicted findings translated into practical aspects strengthen the idea that the isoflavones genistein, daidzein, glycitein, biochanin A, formononetin and equol can be used in various inflammation based diseases as an alternative source for classical medication and that consummation of foods rich in isoflavones may represent prerequisite use in order to prevent the evolution of inflammation based diseases.
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Cite this article as:
Main Isoflavones Found in Dietary Sources as Natural Anti-inflammatory Agents, Current Drug Targets 2018; 19 (7) . https://dx.doi.org/10.2174/1389450118666171109150731
DOI https://dx.doi.org/10.2174/1389450118666171109150731 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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